The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
DNAzyme-Functionalized Au Nanoparticles for the Amplified Detection of DNA or Telomerase Activity
Abstract
DNAzyme-functionalized Au−NPs act as catalytic labels for the amplified detection of DNA and telomerase activity on nucleic acid-functionalized gold surface. The DNAzyme stimulates, in the presence of hemin, H 2 O 2, and luminol, the generation of chemiluminescence. For DNA analysis, a nucleic acid unit complementary to the analyzed DNA is tethered to the DNAzyme structure associated with the Au−NPs. For telomerase activity, a nucleic acid complementary to the telomer repeat units generated on the surface is tethered to the DNAzyme structure associated with the Au−NPs. The detection limit for the detection of DNA is 1 × 10 -10 M. The method enables the detection of telomerase activity originating from 1000 HeLa cells.
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Citations
Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Cited by
Wang, F., Lu, C.-H., & Willner, I. (2014) · Chemical Reviews · doi:10.1021/cr400354z · Cited by 649
Self-citationSynthesis of Gold Nanoparticles Using Multifunctional Peptides
Slocik, J. M., Stone, M. O., & Naik, R. R. (2005) · Small · doi:10.1002/smll.200500172 · Cited by 339
Amplified Analysis of DNA by the Autonomous Assembly of Polymers Consisting of DNAzyme Wires
Wang, F., Elbaz, J., Orbach, R., Magen, N., & Willner, I. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2076789 · Cited by 339
Self-citation
Metadata
- Authors
- Niazov, T., Pavlov, V., Xiao, Y., Gill, R., & Willner, I.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-07-30
- Volume
- 4
- Issue
- 9
- Pages
- 1683-1687
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2079875865
- Cited by
- 288
- References
- 1
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- closed
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