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Switching the Conformation of a DNA Molecule with a Chemical Oscillator
Abstract
pH oscillations generated by a nonequilibrium chemical reaction are used to switch a pH-sensitive DNA structure between two distinct conformations. The utilization of a chemical oscillator represents a novel method for achieving autonomous motion in molecular devices. The oscillatory reaction is a variant of the Landolt reaction and produces pH variations in the range between pH 5 and 7. In this range, a cytosine-rich DNA strand can be switched between a random coil conformation and the folded i-motif structure. The conformational changes are monitored simultaneously with the pH value in fluorescence-resonance energy-transfer experiments.
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Cites
The Geometry of Biological Time
Winfree, A. T. (1980) · doi:10.1007/978-3-662-22492-2 · Cited by 3,613
Cited by
Wang, F., Lu, C.-H., & Willner, I. (2014) · Chemical Reviews · doi:10.1021/cr400354z · Cited by 649
Ashkenasy, G., Hermans, T. M., Otto, S., & Taylor, A. F. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00117g · Cited by 595
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
Structural, mechanical, and thermodynamic properties of a coarse-grained DNA model
Ouldridge, T. E., Louis, A. A., & Doye, J. P. K. (2011) · The Journal of Chemical Physics · doi:10.1063/1.3552946 · Cited by 462
Metadata
- Authors
- Liedl, T., & Simmel, F. C.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-09-27
- Volume
- 5
- Issue
- 10
- Pages
- 1894-1898
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2119635496
- Cited by
- 209
- References
- 1
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
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