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Systematic Investigation of the Thermodynamics of HSA Adsorption to N-iso-Propylacrylamide/N-tert-Butylacrylamide Copolymer Nanoparticles. Effects of Particle Size and Hydrophobicity
Abstract
Nanoparticles in biological fluids almost invariably become coated with proteins that may confer nanomedical and nanotoxicological effects. Understanding these effects requires quantitative measurements using simple systems. Adsorption of HSA to copolymer nanoparticles of varying hydrophobicity and curvature was studied using ITC, yielding stoichiometry, affinity, and enthalpy changes upon binding. The hydrophobicity was controlled via the co-monomer ratio, N-iso-propylacrylamide/N-tert-butylacrylamide. The most hydrophobic particles become fully covered with a single layer of protein, except at high curvature.
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Citations
Cited by
Walkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758
Pozzi, D., Colapicchioni, V., Caracciolo, G., Piovesana, S., Capriotti, A. L., Palchetti, S., De Grossi, S., Riccioli, A., Amenitsch, H., & Laganà, A. (2014) · Nanoscale · doi:10.1039/c3nr05559k · Cited by 581
Xu, Q., Ensign, L. M., Boylan, N. J., Schön, A., Gong, X., Yang, J.-C., Lamb, N. W., Cai, S., Yu, T., Freire, E., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b03876 · Cited by 568
Preformed albumin corona, a protective coating for nanoparticles based drug delivery system
Peng, Q., Zhang, S., Yang, Q., Zhang, T., Wei, X.-Q., Jiang, L., Zhang, C.-L., Chen, Q.-M., Zhang, Z.-R., & Lin, Y.-F. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.102 · Cited by 366
Exploiting the Protein Corona around Gold Nanorods for Loading and Triggered Release
Kah, J. C. Y., Chen, J., Zubieta, A., & Hamad-Schifferli, K. (2012) · ACS Nano · doi:10.1021/nn301389c · Cited by 178
Metadata
- Authors
- Lindman, S., Lynch, I., Thulin, E., Nilsson, H., Dawson, K. A., & Linse, S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-03-03
- Volume
- 7
- Issue
- 4
- Pages
- 914-920
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2090757591
- Cited by
- 377
- References
- 0
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Systematic Investigation of the Thermodynamics of HSA Adsorption to N-iso-Propylacrylamide/N-tert-Butylacrylamide Copolymer Nanoparticles. Effects of Particle Size and Hydrophobicity. https://app.cochat.ai/papers/10.1021/nl062743+
- The paper
- Lindman, S., Lynch, I., Thulin, E., Nilsson, H., Dawson, K. A., & Linse, S. (2007). Systematic Investigation of the Thermodynamics of HSA Adsorption to N-iso-Propylacrylamide/N-tert-Butylacrylamide Copolymer Nanoparticles. Effects of Particle Size and Hydrophobicity. Nano Letters. https://doi.org/10.1021/nl062743%2B
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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