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Plasmonic Nanosensors for Imaging Intracellular Biomarkers in Live Cells
Abstract
Here we present the first intracellular molecular imaging platform using multifunctional gold nanoparticles which incorporate both cytosolic delivery and targeting moieties on the same particle. The utility of these intracellular sensors was demonstrated by monitoring actin rearrangement in live fibroblasts. We observed a strong molecular specific optical signal associated with effective targeting of actin filaments. These multifunctional nanosensors can be adapted to target various intracellular processes especially where transfection or cytotoxic labels are not feasible.
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Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647
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Silica-Coated Gold Nanorods as Photoacoustic Signal Nanoamplifiers
Chen, Y.-S., Frey, W., Kim, S., Kruizinga, P., Homan, K., & Emelianov, S. (2011) · Nano Letters · doi:10.1021/nl1042006 · Cited by 511
Integrating Artificial Intelligence and Nanotechnology for Precision Cancer Medicine
Adir, O., Poley, M., Chen, G., Froim, S., Krinsky, N., Shklover, J., Shainsky‐Roitman, J., Lammers, T., & Schroeder, A. (2020) · Advanced Materials · doi:10.1002/adma.201901989 · Cited by 496
Biofunctionalized silver nanoparticles: Advances and prospects
Ravindran, A., Chandran, P., & Khan, S. S. (2013) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2012.07.036 · Cited by 454
Choi, W. I., Kim, J.-Y., Kang, C., Byeon, C. C., Kim, Y. H., & Tae, G. (2011) · ACS Nano · doi:10.1021/nn103047r · Cited by 433
Metadata
- Authors
- Kumar, S., Harrison, N., Richards-Kortum, R., & Sokolov, K.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-04-17
- Volume
- 7
- Issue
- 5
- Pages
- 1338-1343
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2107011370
- Cited by
- 232
- References
- 1
- FWCI
- 14.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kumar, S., Harrison, N., Richards-Kortum, R., & Sokolov, K. (2007). Plasmonic Nanosensors for Imaging Intracellular Biomarkers in Live Cells. Nano Letters. https://doi.org/10.1021/nl070365i
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
