The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cancer Cells Assemble and Align Gold Nanorods Conjugated to Antibodies to Produce Highly Enhanced, Sharp, and Polarized Surface Raman Spectra: A Potential Cancer Diagnostic Marker
Abstract
Human oral cancer cells are found to assemble and align gold nanorods conjugated to anti-epidermal growth factor receptor (anti-EGFR) antibodies. Immnoconjugated gold nanorods and nanospheres were shown previously to exhibit strong Rayleigh (Mie) scattering useful for imaging. In the present letter, molecules near the nanorods on the cancer cells are found to give a Raman spectrum that is greatly enhanced (due to the high surface plasmon field of the nanorod assembly in which their extended surface plasmon fields overlap), sharp (due to a homogeneous environment), and polarized (due to anisotropic alignments). These observed properties can be used as diagnostic signatures for cancer cells.
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Cites
Raman spectra of pyridine adsorbed at a silver electrode
Fleischmann, M., Hendra, P. J., & McQuillan, A. J. (1974) · Chemical Physics Letters · doi:10.1016/0009-2614(74)85388-1 · Cited by 7,172
Surface raman spectroelectrochemistry
Jeanmaire, D. L., & Van Duyne, R. P. (1977) · Journal of Electroanalytical Chemistry and Interfacial Electrochemistry · doi:10.1016/s0022-0728(77)80224-6 · Cited by 4,738
Cited by
Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
Huang, X., Neretina, S., & El‐Sayed, M. A. (2009) · Advanced Materials · doi:10.1002/adma.200802789 · Cited by 1,921
Self-citationUsing Raman spectroscopy to characterize biological materials
Butler, H. J., Ashton, L., Bird, B., Cinque, G., Curtis, K., Dorney, J., Esmonde-White, K., Fullwood, N. J., Gardner, B., Martin-Hirsch, P. L., et al. (2016) · Nature Protocols · doi:10.1038/nprot.2016.036 · Cited by 1,309
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Plasmonic coupling in noble metal nanostructures
Jain, P. K., & El-Sayed, M. A. (2010) · Chemical Physics Letters · doi:10.1016/j.cplett.2010.01.062 · Cited by 963
Self-citationSurface plasmons in metallic nanoparticles: fundamentals and applications
Garcia, M. A. (2011) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/44/28/283001 · Cited by 907
Metadata
- Authors
- Huang, X., El-Sayed, I. H., Qian, W., & El-Sayed, M. A.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-05-03
- Volume
- 7
- Issue
- 6
- Pages
- 1591-1597
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1998383751
- Cited by
- 518
- References
- 2
- FWCI
- 23.45
- Type
- journal article
- Language
- en
- Open access
- closed
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