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Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent
Abstract
Poly(ethylene glycol)-coated Au nanocages have been evaluated as a potential near-infrared (NIR) contrast agent for photoacoustic tomography (PAT). Previously, Au nanoshells were found to be an effective NIR contrast agent for PAT; however, Au nanocages with their more compact sizes (<50 nm compared to >100 nm for Au nanoshells) and larger optical absorption cross sections should be better suited for in vivo applications. We sequentially injected Au nanocages into the circulatory system of a rat in three administrations and in vivo PAT was conducted immediately prior to the first injection and continued until 5 h after the final injection. A gradual enhancement of the optical absorption in the cerebral cortex, by up to 81%, was observed over the course of the experiment.
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Cited by
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Metadata
- Authors
- Yang, X., Skrabalak, S. E., Li, Z.-Y., Xia, Y., & Wang, L. V.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-11-20
- Volume
- 7
- Issue
- 12
- Pages
- 3798-3802
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2104979069
- Cited by
- 407
- References
- 0
- FWCI
- 18.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, X., Skrabalak, S. E., Li, Z.-Y., Xia, Y., & Wang, L. V. (2007). Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent. Nano Letters. https://doi.org/10.1021/nl072349r
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