The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Templated Synthesis of Single-Component Polymer Capsules and Their Application in Drug Delivery
Open accessAbstract
We report a general and facile approach for the fabrication of a new class of monodispersed, single-component and thick-walled polymer nanocapsules via the single-step assembly of macromolecules in solid core/mesoporous shell (SC/MS) silica particle templates, followed by cross-linking of the macromolecules and removal of the SC/MS templates. The general applicability of this approach is demonstrated by the preparation of nanocapsules using various polymers, including synthetic polyelectrolytes, polypeptides, and polypeptide-drug conjugates. The potential of doxorubicin (Dox)-loaded poly(L-glutamic acid) nanocapsules in tumor therapy applications is demonstrated via in vitro degradation experiments, which show a near-linear release of the Dox in the presence of a lysosomal hydrolase, nanocapsule uptake by human colorectal tumor cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death.
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Citations
Cites
Polymeric systems for controlled drug release
Uhrich, K. E., Cannizzaro, S. M., Langer, R. S., & Shakesheff, K. M. (1999) · Chemical Reviews · doi:10.1021/cr940351u · Cited by 2,633
Cited by
Self-Polymerization of Dopamine as a Versatile and Robust Technique to Prepare Polymer Capsules
Postma, A., Yan, Y., Wang, Y., Zelikin, A. N., Tjipto, E., & Caruso, F. (2009) · Chemistry of Materials · doi:10.1021/cm901293e · Cited by 494
Self-citationPolymeric multilayer capsules for drug delivery
De Koker, S., Hoogenboom, R., & De Geest, B. G. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15296g · Cited by 383
Surface charge-mediated rapid hepatobiliary excretion of mesoporous silica nanoparticles
Souris, J. S., Lee, C.-H., Cheng, S.-H., Chen, C.-T., Yang, C.-S., Ho, J.-A. A., Mou, C.-Y., & Lo, L.-W. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.048 · Cited by 320
Li, W., & Zhao, D. (2013) · Advanced Materials · doi:10.1002/adma.201203547 · Cited by 310
Cui, J., Wang, Y., Postma, A., Hao, J., Hosta‐Rigau, L., & Caruso, F. (2010) · Advanced Functional Materials · doi:10.1002/adfm.201000209 · Cited by 290
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Metadata
- Authors
- Wang, Y., Bansal, V., Zelikin, A. N., & Caruso, F.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-05-20
- Volume
- 8
- Issue
- 6
- Pages
- 1741-1745
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2042274498
- Cited by
- 248
- References
- 1
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, Y., Bansal, V., Zelikin, A. N., & Caruso, F. (2008). Templated Synthesis of Single-Component Polymer Capsules and Their Application in Drug Delivery. Nano Letters. https://doi.org/10.1021/nl080877c
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
