The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Frequency Domain Detection of Biomolecules Using Silicon Nanowire Biosensors
Open accessAbstract
We demonstrate a new protein detection methodology based upon frequency domain electrical measurement using silicon nanowire field-effect transistor (SiNW FET) biosensors. The power spectral density of voltage from a current-biased SiNW FET shows 1/f-dependence in frequency domain for measurements of antibody functionalized SiNW devices in buffer solution or in the presence of protein not specific to the antibody receptor. In the presence of protein (antigen) recognized specifically by the antibody-functionalized SiNW FET, the frequency spectrum exhibits a Lorentzian shape with a characteristic frequency of several kilohertz. Frequency and conventional time domain measurements carried out with the same device as a function of antigen concentration show more than 10-fold increase in detection sensitivity in the frequency domain data. These concentration-dependent results together with studies of antibody receptor density effect further address possible origins of the Lorentzian frequency spectrum. Our results show that frequency domain measurements can be used as a complementary approach to conventional time domain measurements for ultrasensitive electrical detection of proteins and other biomolecules using nanoscale FETs.
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Cites
Label-free immunodetection with CMOS-compatible semiconducting nanowires
Stern, E., Klemic, J. F., Routenberg, D. A., Wyrembak, P. N., Turner-Evans, D. B., Hamilton, A. D., LaVan, D. A., Fahmy, T. M., & Reed, M. A. (2007) · Nature · doi:10.1038/nature05498 · Cited by 1,352
Subthreshold Regime has the Optimal Sensitivity for Nanowire FET Biosensors
Gao, X. P. A., Zheng, G., & Lieber, C. M. (2010) · Nano Letters · doi:10.1021/nl9034219 · Cited by 571
Self-citationKinetic analysis of macromolecular interactions using surface plasmon resonance biosensors
Myszka, D. G. (1997) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(97)80157-7 · Cited by 552
Cited by
Tang, J., Kong, B., Wu, H., Xu, M., Wang, Y., Wang, Y., Zhao, D., & Zheng, G. (2013) · Advanced Materials · doi:10.1002/adma.201303124 · Cited by 567
Self-citationBiosensors based on nanomechanical systems
Tamayo, J., Kosaka, P. M., Ruz, J. J., San Paulo, Á., & Calleja, M. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35293a · Cited by 391
Nanoelectronic Heterodyne Sensor: A New Electronic Sensing Paradigm
Kulkarni, G. S., Zang, W., & Zhong, Z. (2016) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00329 · Cited by 32
Metadata
- Authors
- Zheng, G., Gao, X. P. A., & Lieber, C. M.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-07-13
- Volume
- 10
- Issue
- 8
- Pages
- 3179-3183
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2147163432
- Cited by
- 210
- References
- 3
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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