The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects
Abstract
The interactions of mesoporous silica nanoparticles (MSNs) of different particle sizes and surface properties with human red blood cell (RBC) membranes were investigated by membrane filtration, flow cytometry, and various microscopic techniques. Small MCM-41-type MSNs (∼100 nm) were found to adsorb to the surface of RBCs without disturbing the membrane or morphology. In contrast, adsorption of large SBA-15-type MSNs (∼600 nm) to RBCs induced a strong local membrane deformation leading to spiculation of RBCs, internalization of the particles, and eventual hemolysis. In addition, the relationship between the degree of MSN surface functionalization and the degree of its interaction with RBC, as well as the effect of RBC-MSN interaction on cellular deformability, were investigated. The results presented here provide a better understanding of the mechanisms of RBC-MSN interaction and the hemolytic activity of MSNs and will assist in the rational design of hemocompatible MSNs for intravenous drug delivery and in vivo imaging.
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Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
Liong, M., Lu, J., Kovochich, M., Xia, T., Ruehm, S. G., Nel, A. E., Tamanoi, F., & Zink, J. I. (2008) · ACS Nano · doi:10.1021/nn800072t · Cited by 1,929
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Self-citationMesoporous silica nanoparticles deliver DNA and chemicals into plants
Torney, F., Trewyn, B. G., Lin, V. S.-Y., & Wang, K. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.108 · Cited by 1,481
Self-citationKim, J., Kim, H. S., Lee, N., Kim, T., Kim, H., Yu, T., Song, I. C., Moon, W. K., & Hyeon, T. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200802469 · Cited by 1,220
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Size Effect on Cell Uptake in Well‐Suspended, Uniform Mesoporous Silica Nanoparticles
Lu, F., Wu, S., Hung, Y., & Mou, C. (2009) · Small · doi:10.1002/smll.200900005 · Cited by 1,041
Mesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery
Vivero‐Escoto, J. L., Slowing, I. I., Trewyn, B. G., & Lin, V. S. ‐. (2010) · Small · doi:10.1002/smll.200901789 · Cited by 998
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Self-citationInteraction of Gold Nanoparticles with Common Human Blood Proteins
Lacerda, S. H. D. P., Park, J. J., Meuse, C., Pristinski, D., Becker, M. L., Karim, A., & Douglas, J. F. (2010) · ACS Nano · doi:10.1021/nn9011187 · Cited by 976
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Cited by
Nanoparticles as drug delivery systems
Wilczewska, A. Z., Niemirowicz, K., Markiewicz, K. H., & Car, H. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70901-5 · Cited by 1,445
Engineered nanoparticles interacting with cells: size matters
Shang, L., Nienhaus, K., & Nienhaus, G. U. (2014) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-12-5 · Cited by 1,316
Mesoporous Silica Nanoparticles for Drug Delivery
Manzano, M., & Vallet‐Regí, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201902634 · Cited by 939
Canton, I., & Battaglia, G. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15309b · Cited by 936
Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity
Yu, T., Malugin, A., & Ghandehari, H. (2011) · ACS Nano · doi:10.1021/nn2013904 · Cited by 666
Metadata
- Authors
- Zhao, Y., Sun, X., Zhang, G., Trewyn, B. G., Slowing, I. I., & Lin, V. S.-Y.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-02-04
- Volume
- 5
- Issue
- 2
- Pages
- 1366-1375
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1986231174
- Cited by
- 572
- References
- 54
- FWCI
- 15.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhao, Y., Sun, X., Zhang, G., Trewyn, B. G., Slowing, I. I., & Lin, V. S.-Y. (2011). Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects. ACS Nano. https://doi.org/10.1021/nn103077k
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