The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of Gold Nanorod Surface Chemistry on Cellular Response
Open accessAbstract
Gold nanorods (GNRs) stabilized with cetyltrimethylammonium bromide (CTAB) and GNR functionalized via a ligand exchange method with either thiolated polyethylene glycol (PEG(5000)) or mercaptohexadecanoic acid (MHDA) were investigated for their stability in biological media and subsequent toxicological effects to HaCaT cells. GNR-PEG and GNR-MHDA exhibited minimal effects on cell proliferation, whereas GNR-CTAB reduced cell proliferation significantly due to the inherent toxicity of the cationic surfactant to cells. Cell uptake studies indicated relatively low uptake for GNR-PEG and high uptake for GNR-MHDA. Reverse transcriptase polymerase chain reaction (RT-PCR) revealed that GNR-PEG induced less significant and unique changes in the transcription levels of 84 genes related to stress and toxicity compared to GNR-MHDA. The results demonstrate that, although cell proliferation was not affected by both particles, there is a significant difference in gene expression in GNR-MHDA exposed cells, suggesting long-term implications for chronic exposure.
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Bartneck, M., Keul, H. A., Singh, S., Czaja, K., Bornemann, J., Bockstaller, M., Moeller, M., Zwadlo-Klarwasser, G., & Groll, J. (2010) · ACS Nano · doi:10.1021/nn100262h · Cited by 253
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Kuo, W.-S., Chang, Y.-T., Cho, K.-C., Chiu, K.-C., Lien, C.-H., Yeh, C.-S., & Chen, S.-J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.035 · Cited by 305
Exploiting the Protein Corona around Gold Nanorods for Loading and Triggered Release
Kah, J. C. Y., Chen, J., Zubieta, A., & Hamad-Schifferli, K. (2012) · ACS Nano · doi:10.1021/nn301389c · Cited by 178
Self-citationLaser exposure of gold nanorods can increase neuronal cell outgrowth.
Paviolo, C., Haycock, J. W., Yong, J., Yu, A., Stoddart, P. R., & McArthur, S. L. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.24889 · Cited by 105
Metadata
- Authors
- Grabinski, C., Schaeublin, N., Wijaya, A., D’Couto, H., Baxamusa, S. H., Hamad-Schifferli, K., & Hussain, S. M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-03-23
- Volume
- 5
- Issue
- 4
- Pages
- 2870-2879
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2063172840
- Cited by
- 187
- References
- 1
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Grabinski, C., Schaeublin, N., Wijaya, A., D’Couto, H., Baxamusa, S. H., Hamad-Schifferli, K., & Hussain, S. M. (2011). Effect of Gold Nanorod Surface Chemistry on Cellular Response. ACS Nano. https://doi.org/10.1021/nn103476x
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