The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dynamics of Completely Unfolded and Native Proteins through Solid-State Nanopores as a Function of Electric Driving Force
Abstract
We report experimentally the dynamic properties of the entry and transport of unfolded and native proteins through a solid-state nanopore as a function of applied voltage, and we discuss the experimental data obtained as compared to theory. We show an exponential increase in the event frequency of current blockades and an exponential decrease in transport times as a function of the electric driving force. The normalized current blockage ratio remains constant or decreases for folded or unfolded proteins, respectively, as a function of the transmembrane potential. The unfolded protein is stretched under the electric driving force. The dwell time of native compact proteins in the pore is almost 1 order of magnitude longer than that of unfolded proteins, and the event frequency for both protein conformations is low. We discuss the possible phenomena hindering the transport of proteins through the pores, which could explain these anomalous dynamics, in particular, electro-osmotic counterflow and protein adsorption on the nanopore wall.
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Cites
Reaction-rate theory: fifty years after Kramers
Hänggi, P., Talkner, P., & Borkovec, M. (1990) · Reviews of Modern Physics · doi:10.1103/revmodphys.62.251 · Cited by 6,154
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Rapoport, T. A. (2007) · Nature · doi:10.1038/nature06384 · Cited by 977
Cited by
Real-time shape approximation and fingerprinting of single proteins using a nanopore
Yusko, E. C., Bruhn, B. R., Eggenberger, O. M., Houghtaling, J., Rollings, R. C., Walsh, N. C., Nandivada, S., Pindrus, M., Hall, A. R., Sept, D., et al. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2016.267 · Cited by 473
Paving the way to single-molecule protein sequencing
Restrepo-Pérez, L., Joo, C., & Dekker, C. (2018) · Nature Nanotechnology · doi:10.1038/s41565-018-0236-6 · Cited by 396
Fast Translocation of Proteins through Solid State Nanopores
Plesa, C., Kowalczyk, S. W., Zinsmeester, R., Grosberg, A. Y., Rabin, Y., & Dekker, C. (2013) · Nano Letters · doi:10.1021/nl3042678 · Cited by 381
Metadata
- Authors
- Oukhaled, A., Cressiot, B., Bacri, L., Pastoriza-Gallego, M., Betton, J.-M., Bourhis, E., Jede, R., Gierak, J., Auvray, L., & Pelta, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-04-26
- Volume
- 5
- Issue
- 5
- Pages
- 3628-3638
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2327033711
- Cited by
- 198
- References
- 2
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- closed
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