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NIR-to-NIR Two-Photon Excited CaF2:Tm3+,Yb3+ Nanoparticles: Multifunctional Nanoprobes for Highly Penetrating Fluorescence Bio-Imaging
Open accessAbstract
In this study, we report on the remarkable two-photon excited fluorescence efficiency in the "biological window" of CaF(2):Tm(3+),Yb(3+) nanoparticles. On the basis of the strong Tm(3+) ion emission (at around 800 nm), tissue penetration depths as large as 2 mm have been demonstrated, which are more than 4 times those achievable based on the visible emissions in comparable CaF(2):Er(3+),Yb(3+) nanoparticles. The outstanding penetration depth, together with the fluorescence thermal sensitivity demonstrated here, makes CaF(2):Tm(3+),Yb(3+) nanoparticles ideal candidates as multifunctional nanoprobes for high contrast and highly penetrating in vivo fluorescence imaging applications.
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Cites
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
Cited by
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Wang, X.-D., Wolfbeis, O. S., & Meier, R. J. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60102a · Cited by 1,647
An overview of nanoparticles commonly used in fluorescent bioimaging
Wolfbeis, O. S. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00392f · Cited by 1,631
Zheng, W., Huang, P., Tu, D., Ma, E., Zhu, H., & Chen, X. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00178h · Cited by 894
Chen, G., Shen, J., Ohulchanskyy, T. Y., Patel, N. J., Kutikov, A., Li, Z., Song, J., Pandey, R. K., Ågren, H., Prasad, P. N., et al. (2012) · ACS Nano · doi:10.1021/nn302972r · Cited by 720
Subtissue Thermal Sensing Based on Neodymium-Doped LaF3Nanoparticles
Rocha, U., Jacinto da Silva, C., Ferreira Silva, W., Guedes, I., Benayas, A., Martínez Maestro, L., Acosta Elias, M., Bovero, E., van Veggel, F. C. J. M., García Solé, J. A., et al. (2013) · ACS Nano · doi:10.1021/nn304373q · Cited by 382
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Metadata
- Authors
- Dong, N.-N., Pedroni, M., Piccinelli, F., Conti, G., Sbarbati, A., Ramírez-Hernández, J. E., Maestro, L. M., Iglesias-de la Cruz, M. C., Sanz-Rodriguez, F., Juarranz, A., Chen, F., Vetrone, F., Capobianco, J. A., Solé, J. G., Bettinelli, M., Jaque, D., & Speghini, A.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-10-06
- Volume
- 5
- Issue
- 11
- Pages
- 8665-8671
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2318157802
- Cited by
- 427
- References
- 1
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- green
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