The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Silver Nanoplate Contrast Agents for in Vivo Molecular Photoacoustic Imaging
Open accessAbstract
Silver nanoplates are introduced as a new photoacoustic contrast agent that can be easily functionalized for molecular photoacoustic imaging in vivo. Methods are described for synthesis, functionalization, and stabilization of silver nanoplates using biocompatible ("green") reagents. Directional antibody conjugation to the nanoplate surface is presented along with proof of molecular sensitivity in vitro with pancreatic cancer cells. Cell viability tests show the antibody-conjugated silver nanoplates to be nontoxic at concentrations up to 1 mg/mL. Furthermore, the silver nanoplates' potential for in vivo application as a molecularly sensitive photoacoustic contrast agent is demonstrated using an orthotopic mouse model of pancreatic cancer. Results of these studies suggest that the synthesized silver nanoplates are well suited for a host of biomedical imaging and sensing applications.
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Cites
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662
Cited by
Advances in Diagnostic and Intraoperative Molecular Imaging of Pancreatic Cancer
Tummers, W. S., Willmann, J. K., Bonsing, B. A., Vahrmeijer, A. L., Gambhir, S. S., & Swijnenburg, R.-J. (2018) · Pancreas · doi:10.1097/mpa.0000000000001075 · Cited by 50
Fast and simple synthesis of triangular silver nanoparticles under the assistance of light
Nguyen, T. H. N., Nguyen, T. D., Cao, M. T., & Pham, V. V. (2020) · Colloids and Surfaces A: Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2020.124659 · Cited by 31
Metadata
- Authors
- Homan, K. A., Souza, M., Truby, R., Luke, G. P., Green, C., Vreeland, E., & Emelianov, S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-01-06
- Volume
- 6
- Issue
- 1
- Pages
- 641-650
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2012889021
- Cited by
- 233
- References
- 1
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Homan, K. A., Souza, M., Truby, R., Luke, G. P., Green, C., Vreeland, E., & Emelianov, S. (2012). Silver Nanoplate Contrast Agents for in Vivo Molecular Photoacoustic Imaging. ACS Nano. https://doi.org/10.1021/nn204100n
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