The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Direct Observation of Nanoparticle–Cancer Cell Nucleus Interactions
Open accessAbstract
We report the direct visualization of interactions between drug-loaded nanoparticles and the cancer cell nucleus. Nanoconstructs composed of nucleolin-specific aptamers and gold nanostars were actively transported to the nucleus and induced major changes to the nuclear phenotype via nuclear envelope invaginations near the site of the construct. The number of local deformations could be increased by ultrafast, light-triggered release of the aptamers from the surface of the gold nanostars. Cancer cells with more nuclear envelope folding showed increased caspase 3 and 7 activity (apoptosis) as well as decreased cell viability. This newly revealed correlation between drug-induced changes in nuclear phenotype and increased therapeutic efficacy could provide new insight for nuclear-targeted cancer therapy.
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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
Cited by
Attia, M. F., Anton, N., Wallyn, J., Omran, Z., & Vandamme, T. F. (2019) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13098 · Cited by 1,085
Ghahremani, F., Kefayat, A., Shahbazi-Gahrouei, D., Motaghi, H., Mehrgardi, M. A., & Haghjooy-Javanmard, S. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0180 · Cited by 70
Jo, H., Youn, H., Lee, S., & Ban, C. (2014) · J. Mater. Chem. B · doi:10.1039/c4tb00643g · Cited by 49
Metadata
- Authors
- Dam, D. H. M., Lee, J. H., Sisco, P. N., Co, D. T., Zhang, M., Wasielewski, M. R., & Odom, T. W.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-03-22
- Volume
- 6
- Issue
- 4
- Pages
- 3318-3326
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2065715724
- Cited by
- 276
- References
- 1
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Dam, D. H. M., Lee, J. H., Sisco, P. N., Co, D. T., Zhang, M., Wasielewski, M. R., & Odom, T. W. (2012). Direct Observation of Nanoparticle–Cancer Cell Nucleus Interactions. ACS Nano. https://doi.org/10.1021/nn300296p
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