The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells
Abstract
A highly efficient multifunctional nanoplatform for simultaneous upconversion luminescence (UCL) imaging and photodynamic therapy has been developed on the basis of selective energy transfer from multicolor luminescent NaYF(4):Yb(3+),Er(3+) upconversion nanoparticles (UCNPs) to photosensitizers (PS). Different from popular approaches based on electrostatic or hydrophobic interactions, over 100 photosensitizing molecules were covalently bonded to every 20 nm UCNP, which significantly strengthened the UCNP-PS linkage and reduced the probability of leakage/desorption of the PS. Over 80% UCL was transferred to PS, and the singlet oxygen production was readily detected by its feature emission at 1270 nm. Tests performed on JAR choriocarcinoma and NIH 3T3 fibroblast cells verified the efficient endocytosis and photodynamic effect of the nanoplatform with 980 nm irradiation specific to JAR cancer cells. Our work highlights the promise of using UCNPs for potential image-guided cancer photodynamic therapy.
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Cites
Photodynamic therapy and anti-tumour immunity
Castano, A. P., Mroz, P., & Hamblin, M. R. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1894 · Cited by 2,676
Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
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Upconversion nanophosphors for small-animal imaging
Zhou, J., Liu, Z., & Li, F. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15187h · Cited by 1,581
Wang, F., & Liu, X. (2008) · Journal of the American Chemical Society · doi:10.1021/ja800868a · Cited by 1,458
Self-citationLow, P. S., Henne, W. A., & Doorneweerd, D. D. (2008) · Accounts of Chemical Research · doi:10.1021/ar7000815 · Cited by 1,173
Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals
Chatterjee, D. K., Rufaihah, A. J., & Zhang, Y. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.10.051 · Cited by 988
Self-citationNyk, M., Kumar, R., Ohulchanskyy, T. Y., Bergey, E. J., & Prasad, P. N. (2008) · Nano Letters · doi:10.1021/nl802223f · Cited by 905
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Laser-Tissue Interactions: Fundamentals and Applications
Niemz, M. H. (2019) · doi:10.1007/978-3-030-11917-1 · Cited by 818
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Cited by
Near-Infrared Polymer Dots with Aggregation-Induced Emission for Tumor Imaging
Zhang, Z., Chen, D., Liu, Z., Wang, D., Guo, J., Zheng, J., Qin, W., & Wu, C. (2020) · ACS Applied Polymer Materials · doi:10.1021/acsapm.9b00977 · Cited by 35
Metadata
- Authors
- Liu, K., Liu, X., Zeng, Q., Zhang, Y., Tu, L., Liu, T., Kong, X., Wang, Y., Cao, F., Lambrechts, S. A. G., Aalders, M. C. G., & Zhang, H.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-06
- Volume
- 6
- Issue
- 5
- Pages
- 4054-4062
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2162558082
- Cited by
- 382
- References
- 38
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, K., Liu, X., Zeng, Q., Zhang, Y., Tu, L., Liu, T., Kong, X., Wang, Y., Cao, F., Lambrechts, S. A. G., Aalders, M. C. G., & Zhang, H. (2012). Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells. ACS Nano. https://doi.org/10.1021/nn300436b
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