The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Biocompatible Carbon Nanotube–Chitosan Scaffold Matching the Electrical Conductivity of the Heart
Open accessAbstract
The major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal transduction results in arrhythmias when the scaffolds are implanted. We report that small, subtoxic concentrations of single-walled carbon nanotubes, on the order of tens of parts per million, incorporated in a gelatin-chitosan hydrogel act as electrical nanobridges between cardiomyocytes, resulting in enhanced electrical coupling, synchronous beating, and cardiomyocyte function. These engineered tissues achieve excitation conduction velocities similar to native myocardial tissue (22 ± 9 cm/s) and could function as a full-thickness patch for several cardiovascular defect repair procedures, such as right ventricular outflow track repair for Tetralogy of Fallot, atrial and ventricular septal defect repair, and other cardiac defects, without the risk of inducing cardiac arrhythmias.
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Cites
“Nonswellable” Hydrogel Without Mechanical Hysteresis
Kamata, H., Akagi, Y., Kayasuga-Kariya, Y., Chung, U.-I., & Sakai, T. (2014) · Science · doi:10.1126/science.1247811 · Cited by 669 · cited 1×
“One common feature of engineered hydrogels made from natural components is a high swelling ratio that drastically weakens the mechanical strength during tissue regeneration.(56) The swelling ratio of the”
BackgroundMultimodal optical sensing and analyte specificity using single-walled carbon nanotubes
Heller, D. A., Jin, H., Martinez, B. M., Patel, D., Miller, B. M., Yeung, T.-K., Jena, P. V., Höbartner, C., Ha, T., Silverman, S. K., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2008.369 · Cited by 319
Cited by
Yuk, H., Lu, B., & Zhao, X. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00595h · Cited by 2,108
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Navaei, A., Saini, H., Christenson, W., Sullivan, R. T., Ros, R., & Nikkhah, M. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.05.027 · Cited by 386
Nanocomposite hydrogels for tissue engineering applications
Zhao, H., Liu, M., Zhang, Y., Yin, J., & Pei, R. (2020) · Nanoscale · doi:10.1039/d0nr03785k · Cited by 258
Metadata
- Authors
- Pok, S., Vitale, F., Eichmann, S. L., Benavides, O. M., Pasquali, M., & Jacot, J. G.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-09-29
- Volume
- 8
- Issue
- 10
- Pages
- 9822-9832
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2047205784
- Cited by
- 225
- References
- 2
- FWCI
- 15.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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