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pH-Controlled Gas-Generating Mineralized Nanoparticles: A Theranostic Agent for Ultrasound Imaging and Therapy of Cancers
Open accessAbstract
We report a theranostic nanoparticle that can express ultrasound (US) imaging and simultaneous therapeutic functions for cancer treatment. We developed doxorubicin-loaded calcium carbonate (CaCO3) hybrid nanoparticles (DOX-CaCO3-MNPs) through a block copolymer templated in situ mineralization approach. The nanoparticles exhibited strong echogenic signals at tumoral acid pH by producing carbon dioxide (CO2) bubbles and showed excellent echo persistence. In vivo results demonstrated that the DOX-CaCO3-MNPs generated CO2 bubbles at tumor tissues sufficient for echogenic reflectivity under a US field. In contrast, the DOX-CaCO3-MNPs located in the liver or tumor-free subcutaneous area did not generate the CO2 bubbles necessary for US contrast. The DOX-CaCO3-MNPs could also trigger the DOX release simultaneously with CO2 bubble generation at the acidic tumoral environment. The DOX-CaCO3-MNPs displayed effective antitumor therapeutic activity in tumor-bearing mice. The concept described in this work may serve as a useful guide for development of various theranostic nanoparticles for US imaging and therapy of various cancers.
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Citations
Cited by
Ultrasound‐Activated Sensitizers and Applications
Lin, X., Song, J., Chen, X., & Yang, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201906823 · Cited by 501
Self-citationVersatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications
Zhao, N., Yan, L., Zhao, X., Chen, X., Li, A., Zheng, D., Zhou, X., Dai, X., & Xu, F.-J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00401 · Cited by 429
Self-citationLyu, Y., Zeng, J., Jiang, Y., Zhen, X., Wang, T., Qiu, S., Lou, X., Gao, M., & Pu, K. (2018) · ACS Nano · doi:10.1021/acsnano.7b08616 · Cited by 357
Wang, Q., Chan, K. F., Schweizer, K., Du, X., Jin, D., Yu, S. C. H., Nelson, B. J., & Zhang, L. (2021) · Science Advances · doi:10.1126/sciadv.abe5914 · Cited by 348
Dong, Z., Feng, L., Zhu, W., Sun, X., Gao, M., Zhao, H., Chao, Y., & Liu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.025 · Cited by 284
Metadata
- Authors
- Min, K. H., Min, H. S., Lee, H. J., Park, D. J., Yhee, J. Y., Kim, K., Kwon, I. C., Jeong, S. Y., Silvestre, O. F., Chen, X., Hwang, Y.-S., Kim, E.-C., & Lee, S. C.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-01-08
- Volume
- 9
- Issue
- 1
- Pages
- 134-145
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2015831930
- Cited by
- 265
- References
- 0
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Min, K. H., Min, H. S., Lee, H. J., Park, D. J., Yhee, J. Y., Kim, K., Kwon, I. C., Jeong, S. Y., Silvestre, O. F., Chen, X., Hwang, Y.-S., Kim, E.-C., & Lee, S. C. (2015). pH-Controlled Gas-Generating Mineralized Nanoparticles: A Theranostic Agent for Ultrasound Imaging and Therapy of Cancers. ACS Nano. https://doi.org/10.1021/nn506210a
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