The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Toxicity of Single-Walled Carbon Nanohorns
Abstract
We extensively investigated in vitro and in vivo the toxicities of as-grown single-walled carbon nanohorns (SWNHs), a tubular nanocarbon containing no metal impurity. The SWNHs were found to be a nonirritant and a nondermal sensitizer through skin primary and conjunctival irritation tests and skin sensitization test. Negative mutagenic and clastogenic potentials suggest that SWNHs are not carcinogenic. The acute peroral toxicity of SWNHs was found to be quite low--the lethal dosage for rats was more than 2000 mg/kg of body weight. Intratracheal instillation tests revealed that SWNHs rarely damaged rat lung tissue for a 90-day test period, although black pigmentation due to accumulated nanohorns was observed. While further toxicological assessments, including chronic (repeated dose), reproductive, and developmental toxicity studies, are still needed, yet the present results strongly suggest that as-grown SWNHs have low acute toxicities.
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Donaldson, K., Aitken, R., Tran, L., Stone, V., Duffin, R., Forrest, G., & Alexander, A. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj130 · Cited by 1,167
Driscoll, K. E. (2000) · Toxicological Sciences · doi:10.1093/toxsci/55.1.24 · Cited by 578
Cited by
Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Structure, Properties, Functionalization, and Applications of Carbon Nanohorns
Karousis, N., Suarez-Martinez, I., Ewels, C. P., & Tagmatarchis, N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00611 · Cited by 474
Metadata
- Authors
- Miyawaki, J., Yudasaka, M., Azami, T., Kubo, Y., & Iijima, S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-01-16
- Volume
- 2
- Issue
- 2
- Pages
- 213-226
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1982372788
- Cited by
- 241
- References
- 2
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Miyawaki, J., Yudasaka, M., Azami, T., Kubo, Y., & Iijima, S. (2008). Toxicity of Single-Walled Carbon Nanohorns. ACS Nano. https://doi.org/10.1021/nn700185t
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