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Selective Release of Multiple DNA Oligonucleotides from Gold Nanorods
Open accessAbstract
Combination therapy, or the use of multiple drugs, has been proven to be effective for complex diseases, but the differences in chemical properties and pharmacokinetics can be challenging in terms of the loading, delivering, and releasing multiple drugs. Here we demonstrate that we can load and selectively release two different DNA oligonucleotides from two different gold nanorods. DNA was loaded on the nanorods via thiol conjugation. Selective releases were induced by selective melting of gold nanorods via ultrafast laser irradiation at the nanorods' longitudinal surface plasmon resonance peaks. Excitation at one wavelength could selectively melt one type of gold nanorods and selectively release one type of DNA strand. Releases were efficient (50-80%) and externally tunable by laser fluence. Released oligonucleotides were still functional. This proof of concept is potentially a powerful method for multiple-drug delivery strategies.
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Cites
Multi-pulse drug delivery from a resorbable polymeric microchip device
Grayson, A. C. R., Choi, I. S., Tyler, B. M., Wang, P. P., Brem, H., Cima, M. J., & Langer, R. (2003) · Nature Materials · doi:10.1038/nmat998 · Cited by 444
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Optical Studies of Dynamics in Noble Metal Nanostructures
Hartland, G. V. (2011) · Chemical Reviews · doi:10.1021/cr1002547 · Cited by 1,526
Cutler, J. I., Auyeung, E., & Mirkin, C. A. (2012) · Journal of the American Chemical Society · doi:10.1021/ja209351u · Cited by 1,119
Wang, F., Wang, Y.-C., Dou, S., Xiong, M.-H., Sun, T.-M., & Wang, J. (2011) · ACS Nano · doi:10.1021/nn200007z · Cited by 813
Neural recording and modulation technologies
Chen, R., Canales, A., & Anikeeva, P. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.93 · Cited by 655
The importance of nanoparticle shape in cancer drug delivery
Truong, N. P., Whittaker, M. R., Mak, C. W., & Davis, T. P. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.950564 · Cited by 594
Metadata
- Authors
- Wijaya, A., Schaffer, S. B., Pallares, I. G., & Hamad-Schifferli, K.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-12-16
- Volume
- 3
- Issue
- 1
- Pages
- 80-86
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2058574114
- Cited by
- 420
- References
- 1
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- green
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