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Cited by 504

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Paramagnetic Ultrasmall Gadolinium Oxide Nanoparticles as Advanced T1 MRI Contrast Agent: Account for Large Longitudinal Relaxivity, Optimal Particle Diameter, and In Vivo T1 MR Images

Park, Ja Young, Baek, Myung Ju, Choi, Eun Sook, Woo, Seungtae, Kim, Joo Hyun, Kim, Tae Jeong, Jung, Jae Chang, Chae, Kwon Seok, Chang, Yongmin, Lee, Gang Ho·2009·ACS Nano

Abstract

Paramagnetic ultrasmall gadolinium oxide (Gd(2)O(3)) nanoparticles with particle diameters (d) of approximately 1 nm were synthesized by using three kinds of Gd(III) ion precursors and by refluxing each of them in tripropylene glycol under an O(2) flow. A large longitudinal relaxivity (r(1)) of water proton of 9.9 s(-1) mM(-1) was estimated. As a result, high contrast in vivo T(1) MR images of the brain tumor of a rat were observed. This large r(1) is discussed in terms of the huge surface to volume ratio (S/V) of the ultrasmall gadolinium oxide nanoparticles coupled with the cooperative induction of surface Gd(III) ions for the longitudinal relaxation of a water proton. It is found from the d dependence of r(1) that the optimal range of d for the maximal r(1), which may be used as an advanced T(1) MRI contrast agent, is 1-2.5 nm.

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Metadata

Authors
Park, J. Y., Baek, M. J., Choi, E. S., Woo, S., Kim, J. H., Kim, T. J., Jung, J. C., Chae, K. S., Chang, Y., & Lee, G. H.
Venue
ACS Nano
Published
2009-10-16
Volume
3
Issue
11
Pages
3663-3669
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W2035855761
Cited by
504
References
1
FWCI
9.89
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Paramagnetic Ultrasmall Gadolinium Oxide Nanoparticles as Advanced T1 MRI Contrast Agent: Account for Large Longitudinal Relaxivity, Optimal Particle Diameter, and In Vivo T1 MR Images. https://app.cochat.ai/papers/10.1021/nn900761s
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Park, J. Y., Baek, M. J., Choi, E. S., Woo, S., Kim, J. H., Kim, T. J., Jung, J. C., Chae, K. S., Chang, Y., & Lee, G. H. (2009). Paramagnetic Ultrasmall Gadolinium Oxide Nanoparticles as Advanced T1 MRI Contrast Agent: Account for Large Longitudinal Relaxivity, Optimal Particle Diameter, and In Vivo T1 MR Images. ACS Nano. https://doi.org/10.1021/nn900761s

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