The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Recent Advances in the Chemistry of Taxol
Abstract
The history of the development of the important anticancer drug taxol (1) is briefly described, and recent studies of its chemistry and tubulin-binding conformation are then presented. Topics discussed include side chain attachment to baccatin III (3a), the effect of oxygenation of the taxane ring system on bioactivity, the importance of the oxetane ring for bioactivity, the synthesis of a C-6/C-4 bridged analogue, and the conformation of the side chain when taxol is bound in a complex with polymerized tubulin.
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Citations
Cites
Promotion of microtubule assembly in vitro by taxol
SCHIFF, P. B., FANT, J., & HORWITZ, S. B. (1979) · Nature · doi:10.1038/277665a0 · Cited by 3,600
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Cragg, G., & Newman, D. (2001) · Pharmaceutical Biology · doi:10.1076/phbi.39.7.8.5868 · Cited by 448
Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer
Kampan, N. C., Madondo, M. T., McNally, O. M., Quinn, M., & Plebanski, M. (2015) · BioMed Research International · doi:10.1155/2015/413076 · Cited by 362
Wilson, S. A., & Roberts, S. C. (2012) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2011.00664.x · Cited by 358
Peterson, J. R., & Mitchison, T. J. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00284-3 · Cited by 307
Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy
Sharifi-Rad, J., Quispe, C., Patra, J. K., Singh, Y. D., Panda, M. K., Das, G., Adetunji, C. O., Michael, O. S., Sytar, O., Polito, L., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3687700 · Cited by 298
Metadata
- Authors
- Kingston, D. G. I.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-04-12
- Volume
- 63
- Issue
- 5
- Pages
- 726-734
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2094066101
- Cited by
- 172
- References
- 1
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
