The DOI matches its Crossref record.
Current Developments in the Discovery and Design of New Drug Candidates from Plant Natural Product Leads,
Abstract
This review article will emphasize recent research in the Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, on various classes of plant-derived compounds that possess potent antitumor or anti-HIV activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analogue synthesis. Structural modification, SAR, and mechanism of action studies are discussed.
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Citations
Cited by
Natural products: A lead for drug discovery and development
Chopra, B., & Dhingra, A. K. (2021) · Phytotherapy Research · doi:10.1002/ptr.7099 · Cited by 469
Lee, K.-H. (2010) · Journal of Natural Products · doi:10.1021/np900821e · Cited by 278
Self-citationMelagraki, G., Afantitis, A., Igglessi-Markopoulou, O., Detsi, A., Koufaki, M., Kontogiorgis, C., & Hadjipavlou-Litina, D. J. (2009) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2008.12.027 · Cited by 272
HIV‐1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design
Zhan, P., Chen, X., Li, D., Fang, Z., De Clercq, E., & Liu, X. (2013) · Medicinal Research Reviews · doi:10.1002/med.20241 · Cited by 192
Metadata
- Authors
- Lee, K.-H.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-12-03
- Volume
- 67
- Issue
- 2
- Pages
- 273-283
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2130235760
- Cited by
- 165
- References
- 0
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Current Developments in the Discovery and Design of New Drug Candidates from Plant Natural Product Leads,. https://app.cochat.ai/papers/10.1021/np030373o
- The paper
- Lee, K.-H. (2004). Current Developments in the Discovery and Design of New Drug Candidates from Plant Natural Product Leads,. Journal of Natural Products. https://doi.org/10.1021/np030373o
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
