The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Scopularides A and B, Cyclodepsipeptides from a Marine Sponge-Derived Fungus, Scopulariopsis brevicaulis
Abstract
Two novel cyclodepsipeptides, scopularides A and B, were found in the fungus Scopulariopsis brevicaulis, which was isolated from the marine sponge Tethya aurantium. In addition, the known fungal metabolite paxilline was identified. The structures of the scopularides were elucidated by NMR, MS, and chemical derivatization methods as cyclo-(3-hydroxy-4-methyldecanoyl-Gly-L-Val-D-Leu-L-Ala-L-Phe) and cyclo-(3-hydroxy-4-methyloctanoyl-Gly-L-Val-D-Leu-L-Ala-L-Phe) for scopularide A and B, respectively. Antibiotic activity against Gram-negative bacteria was absent and against Gram-positive bacteria was weak, but activity against several tumor cell lines was significant at 10 microg/mL.
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“Two novel cyclodepsipeptides, namely, scopularide A and B, isolated from the marine fungus Scopulariopsis brevicaulis [186], significantly inhibited the growth of pancreatic and colon cancer cell lines.”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [186]
Citations
Cites
Brückner, H. J., & Keller-Hoehl, C. (1990) · Chromatographia · doi:10.1007/bf02269735 · Cited by 112
Scopulariopsis brevicaulis, a Fungal Pathogen Resistant to Broad-Spectrum Antifungal Agents
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Namatame, I., Tomoda, H., Ishibashi, S., & Ōmura, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307757100 · Cited by 96
The Modified Mosher’s Method and the Sulfoximine Method
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Self-citationThe production of trimethylarsine by Penicillium brevicaule (Scopulariopsis brevicaulis)
Challenger, F., & Higginbottom, C. (1935) · Biochemical Journal · doi:10.1042/bj0291757 · Cited by 48
Confirmation of the aerobic production of trimethylstibine by Scopulariopsis brevicaulis
Andrewes, P., Cullen, W., & Polishchuk, E. (1999) · Applied Organometallic Chemistry · doi:10.1002/(sici)1099-0739(199909)13:9 · Cited by 27
Research works printed but not linked: 3
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- Springer J. P., 1975, Tetrahedron Lett., 2531, 2534
- Wickerham L. J., 1951, U.S. Dept. Agric. Wash. D.C., Technol. Bull., 1029, 1
Cited by
Sorted by citations
Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555
“Two novel cyclodepsipeptides, namely, scopularide A and B, isolated from the marine fungus Scopulariopsis brevicaulis [186], significantly inhibited the growth of pancreatic and colon cancer cell lines.”
BackgroundAntitumor Peptides from Marine Organisms
Zheng, L.-H., Wang, Y.-J., Sheng, J., Wang, F., Zheng, Y., Lin, X.-K., & Sun, M. (2011) · Marine Drugs · doi:10.3390/md9101840 · Cited by 146
Metadata
- Authors
- Yu, Z., Lang, G., Kajahn, I., Schmaljohann, R., & Imhoff, J. F.
- Affiliations
- GEOMAR Helmholtz Centre for Ocean Research Kiel (DE)
- Corresponding author
- Imhoff, Johannes F.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-04-16
- Volume
- 71
- Issue
- 6
- Pages
- 1052-1054
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2035144900
- Cited by
- 108
- References
- 12
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 6 · 2013: 10 · 2012: 5
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- cyclodepsipeptides, Scopulariopsis brevicaulis, paxilline, structure elucidation, anticancer activity, fungal metabolites
- MeSH terms
- Animals, Anti-Bacterial Agents, Antineoplastic Agents, Drug Screening Assays, Antitumor, Fungi, Humans, Marine Biology, Microbial Sensitivity Tests, Porifera, Molecular Structure, Croatia, Depsipeptides
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