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Additional Bioactive Compounds and Trilobacin, a Novel Highly Cytotoxic Acetogenin, from the Bark of Asimina triloba
Abstract
Fractionation of the EtOH extract of the bark of Asimina triloba, monitoring by brine shrimp lethality, has led to the isolation and structural elucidation of a novel highly cytotoxic Annonaceous acetogenin, trilobacin [1], in addition to six known compounds: asimicin 2], bullatacin [3], bullatacinone [4], N-p-coumaroyltyramine [5], N-trans-feruloyltyramine [6], and (+)-syringaresinol [7]. Acetogenin 1 was identified as a diastereomer of asimicin [2] by spectral and chemical methods, and both 1 and 2 showed potent and selective cytotoxicities in the NCI human tumor cell line screen.
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Citations
Cited by
Paw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products
McLaughlin, J. L. (2008) · Journal of Natural Products · doi:10.1021/np800191t · Cited by 294
Self-citationXie, L.-W., Atanasov, A. G., Guo, D.-A., Malainer, C., Zhang, J.-X., Zehl, M., Guan, S.-H., Heiss, E. H., Urban, E., Dirsch, V. M., et al. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.01.029 · Cited by 76
Park, J. B., & Schoene, N. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6752 · Cited by 48
Intensive Selective Deer Browsing Favors Success of Asimina triloba(Paw Paw) a Native Tree Species
Slater, M. A., & Anderson, R. C. (2014) · Natural Areas Journal · doi:10.3375/043.034.0207 · Cited by 20
Metadata
- Authors
- Zhao, G., Hui, Y., Rupprecht, J. K., McLaughlin, J. L., & Wood, K. V.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1992-03
- Volume
- 55
- Issue
- 3
- Pages
- 347-356
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2079412234
- Cited by
- 161
- References
- 0
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Additional Bioactive Compounds and Trilobacin, a Novel Highly Cytotoxic Acetogenin, from the Bark of Asimina triloba. https://app.cochat.ai/papers/10.1021/np50081a011
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- Zhao, G., Hui, Y., Rupprecht, J. K., McLaughlin, J. L., & Wood, K. V. (1992). Additional Bioactive Compounds and Trilobacin, a Novel Highly Cytotoxic Acetogenin, from the Bark of Asimina triloba. Journal of Natural Products. https://doi.org/10.1021/np50081a011
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