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Antimalarial Activity of Tropical Meliaceae Extracts and Gedunin Derivatives
Abstract
Extracts of 22 species of Meliaceae were examined for antimalarial activity using in vitro tests with two clones of Plasmodium falciparum, one sensitive to chloroquine (W2) and one chloroquine-resistant (D6). Twelve extracts were found to have activity, including extracts of Cedrela odorata wood and Azadirachta indica leaves, which contained the limonoid gedunin. These extracts were more effective against the W2 clone than the D6 clone, suggesting there is no cross-resistance to chloroquine. Gedunin was extracted in quantity, and nine derivatives prepared for a structure-activity study, which revealed essential functionalities for activity. The study also included four other limonoids derived from related Meliaceae. Only gedunin had better activity than chloroquine against the W2 clone. This active principle could be used to standardize a popular crude drug based on traditional use of A. indica in West Africa.
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Citations
Cited by
Meliaceous Limonoids: Chemistry and Biological Activities
Tan, Q.-G., & Luo, X.-D. (2011) · Chemical Reviews · doi:10.1021/cr9004023 · Cited by 474
Natural products as antiparasitic drugs
Kayser, O., Kiderlen, A. F., & Croft, S. L. (2003) · Parasitology Research · doi:10.1007/s00436-002-0768-3 · Cited by 373
Geck, M. S., Cristians, S., Berger-González, M., Casu, L., Heinrich, M., & Leonti, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01160 · Cited by 74
Metadata
- Authors
- MacKinnon, S., Durst, T., Arnason, J. T., Angerhofer, C., Pezzuto, J., Sanchez-Vindas, P. E., Poveda, L. J., & Gbeassor, M.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-04-01
- Volume
- 60
- Issue
- 4
- Pages
- 336-341
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2080163621
- Cited by
- 201
- References
- 0
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- MacKinnon, S., Durst, T., Arnason, J. T., Angerhofer, C., Pezzuto, J., Sanchez-Vindas, P. E., Poveda, L. J., & Gbeassor, M. (1997). Antimalarial Activity of Tropical Meliaceae Extracts and Gedunin Derivatives. Journal of Natural Products. https://doi.org/10.1021/np9605394
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