The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones Using Microwave Irradiation
Abstract
[reaction: see text] A simple, high-yielding synthesis of 2,4,5-trisubstituted imidazoles from 1,2-diketones and aldehydes in the presence of NH(4)OAc is described. Under microwave irradiation, alkyl-, aryl-, and heteroaryl-substituted imidazoles are formed in yields ranging from 80 to 99%. Short syntheses of lepidiline B and trifenagrel illustrate the utility of this approach.
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Cites
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661
Cited by
Solvent-Free Heterocyclic Synthesis
Martins, M. A. P., Frizzo, C. P., Moreira, D. N., Buriol, L., & Machado, P. (2009) · Chemical Reviews · doi:10.1021/cr9001098 · Cited by 638
Imidazoles as potential anticancer agents
Ali, I., Lone, M. N., & Aboul-Enein, H. Y. (2017) · Med. Chem. Commun. · doi:10.1039/c7md00067g · Cited by 409
More Sustainable Approaches for the Synthesis of N-Based Heterocycles
Candeias, N. R., Branco, L. C., Gois, P. M. P., Afonso, C. A. M., & Trindade, A. F. (2009) · Chemical Reviews · doi:10.1021/cr800462w · Cited by 403
Synthesis and biological activity of vicinal diaryl-substituted 1H-imidazoles
Bellina, F., Cauteruccio, S., & Rossi, R. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.02.075 · Cited by 254
Metadata
- Authors
- Wolkenberg, S. E., Wisnoski, D. D., Leister, W. H., Wang, Y., Zhao, Z., & Lindsley, C. W.
- Venue
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-03-27
- Volume
- 6
- Issue
- 9
- Pages
- 1453-1456
- ISSN
- 1523-7052 (ISSN-L)
- 1523-7060
- OpenAlex
- W2022348800
- Cited by
- 432
- References
- 1
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- closed
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