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Nickel-Catalyzed Oxidative Coupling Reactions of Two Different Terminal Alkynes Using O2 as the Oxidant at Room Temperature: Facile Syntheses of Unsymmetric 1,3-Diynes
Abstract
Two different terminal alkynes now can be coupled together in the presence of NiCl(2).6H(2)O/CuI by using an excess of one of the terminal alkyne substrates. The new method employed 20 mol % TMEDA as the ligand and environmentally benign O(2) or air as the oxidant. It is the first example using Ni-salt as catalyst by employing air or O(2) as oxidant, which led to efficient heterocoupling of two different alkynes.
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Cited by
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Allen, S. E., Walvoord, R. R., Padilla-Salinas, R., & Kozlowski, M. C. (2013) · Chemical Reviews · doi:10.1021/cr300527g · Cited by 1,621
Parasram, M., & Gevorgyan, V. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00226b · Cited by 462
Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells
Yamakoshi, H., Dodo, K., Palonpon, A., Ando, J., Fujita, K., Kawata, S., & Sodeoka, M. (2012) · Journal of the American Chemical Society · doi:10.1021/ja308529n · Cited by 461
Zhang, G., Liu, C., Yi, H., Meng, Q., Bian, C., Chen, H., Jian, J.-X., Wu, L.-Z., & Lei, A. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b05665 · Cited by 381
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Metadata
- Authors
- Yin, W., He, C., Chen, M., Zhang, H., & Lei, A.
- Venue
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-12-24
- Volume
- 11
- Issue
- 3
- Pages
- 709-712
- ISSN
- 1523-7052 (ISSN-L)
- 1523-7060
- OpenAlex
- W2027960245
- Cited by
- 266
- References
- 0
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
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