The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals
Abstract
This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
Roughley, S. D., & Jordan, A. M. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200187y · Cited by 2,725
Amide bond formation: beyond the myth of coupling reagents
Valeur, E., & Bradley, M. (2009) · Chem. Soc. Rev. · doi:10.1039/b701677h · Cited by 2,198
Rethinking amide bond synthesis
Pattabiraman, V. R., & Bode, J. W. (2011) · Nature · doi:10.1038/nature10702 · Cited by 2,164
Analysis of the reactions used for the preparation of drug candidate molecules
Carey, J. S., Laffan, D., Thomson, C., & Williams, M. T. (2006) · Organic & Biomolecular Chemistry · doi:10.1039/b602413k · Cited by 1,915
Magano, J., & Dunetz, J. R. (2011) · Chemical Reviews · doi:10.1021/cr100346g · Cited by 1,860
Self-citationAmide bond formation and peptide coupling
Montalbetti, C. A. G. N., & Falque, V. (2005) · Tetrahedron · doi:10.1016/j.tet.2005.08.031 · Cited by 1,786
König, W., & Geiger, R. (1970) · Chemische Berichte · doi:10.1002/cber.19701030319 · Cited by 1,577
1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive
Carpino, L. A. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00063a082 · Cited by 1,489
Microwave assisted organic reactions
Caddick, S. (1995) · Tetrahedron · doi:10.1016/0040-4020(95)00662-r · Cited by 1,435
Direct Synthesis of Amides from Alcohols and Amines with Liberation of H 2
Gunanathan, C., Ben-David, Y., & Milstein, D. (2007) · Science · doi:10.1126/science.1145295 · Cited by 1,288
Cited by
Ynamides as Racemization-Free Coupling Reagents for Amide and Peptide Synthesis
Hu, L., Xu, S., Zhao, Z., Yang, Y., Peng, Z., Yang, M., Wang, C., & Zhao, J. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b07230 · Cited by 267
Kekessie, I., Wegner, K., Martinez, I., Kopach, M. E., White, T. D., Tom, J. K., Kenworthy, M. N., Gallou, F., Lopez, J., Koenig, S. G., et al. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.3c01494 · Cited by 149
Practical N-to-C peptide synthesis with minimal protecting groups
(2023) · doi:10.1038/s42004-023-01030-0 · Cited by 27
Metadata
- Authors
- Dunetz, J. R., Magano, J., & Weisenburger, G. A.
- Venue
- Organic Process Research & Development
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-02-05
- Volume
- 20
- Issue
- 2
- Pages
- 140-177
- ISSN
- 1083-6160 (ISSN-L)
- 1520-586X
- OpenAlex
- W2286942279
- Cited by
- 819
- References
- 105
- FWCI
- 16.60
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals. https://app.cochat.ai/papers/10.1021/op500305s
- The paper
- Dunetz, J. R., Magano, J., & Weisenburger, G. A. (2016). Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals. Organic Process Research & Development. https://doi.org/10.1021/op500305s
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
