The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Noninvasive Urinary Metabonomic Diagnosis of Human Bladder Cancer
Abstract
Cystoscopy is considered the gold standard for the clinical diagnosis of human bladder cancer (BC). As cystoscopy is expensive and invasive, it may compromise patients' compliance and account for the failure in detecting recurrent BC in some patients. In this paper, we investigated the role of urinary metabonomics in the diagnosis of human BC. Gas chromatography/time-of-flight mass spectrometry was applied for the urinary metabolic profiling of 24 BC patients and 51 non-BC controls. The acquired data were analyzed using multivariate principal component analysis followed by orthogonal partial least-squares discriminant analysis (OPLS-DA). Model validity was verified using permutation tests and receiver operating characteristic (ROC) analysis. BC patients were clearly distinguished from non-BC subjects based on their global urinary metabolic profiles (OPLS-DA, 4 latent variables, R(2)X = 0.420, R(2)Y = 0.912 and Q(2) (cumulative) = 0.245; ROC AUC of 0.90; 15 marker metabolites). One-hundred percent sensitivity in detecting BC was observed using urinary metabonomics versus 33% sensitivity achieved by urinary cytology. Additionally, urinary metabonomics exhibited potential in the staging and grading of bladder tumors. In summary, urinary metabonomics is amenable for the noninvasive diagnosis of human BC.
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Cites
van den Berg, R. A., Hoefsloot, H. C., Westerhuis, J. A., Smilde, A. K., & van der Werf, M. J. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-142 · Cited by 2,450
Cited by
Bouatra, S., Aziat, F., Mandal, R., Guo, A. C., Wilson, M. R., Knox, C., Bjorndahl, T. C., Krishnamurthy, R., Saleem, F., Liu, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073076 · Cited by 1,449
Metabolomics in cancer research and emerging applications in clinical oncology
Schmidt, D. R., Patel, R., Kirsch, D. G., Lewis, C. A., Vander Heiden, M. G., & Locasale, J. W. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21670 · Cited by 648
Mass spectrometric based approaches in urine metabolomics and biomarker discovery
Khamis, M. M., Adamko, D. J., & El‐Aneed, A. (2017) · Mass Spectrometry Reviews · doi:10.1002/mas.21455 · Cited by 342
Pasikanti, K. K., Esuvaranathan, K., Hong, Y., Ho, P. C., Mahendran, R., Raman Nee Mani, L., Chiong, E., & Chan, E. C. Y. (2013) · Journal of Proteome Research · doi:10.1021/pr4000448 · Cited by 113
Self-citationYilmaz, A., Ugur, Z., Bisgin, H., Akyol, S., Bahado-Singh, R., Wilson, G., Imam, K., Maddens, M. E., & Graham, S. F. (2020) · Metabolites · doi:10.3390/metabo10090357 · Cited by 65
Metadata
- Authors
- Pasikanti, K. K., Esuvaranathan, K., Ho, P. C., Mahendran, R., Kamaraj, R., Wu, Q. H., Chiong, E., & Chan, E. C. Y.
- Venue
- Journal of Proteome Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-04-26
- Volume
- 9
- Issue
- 6
- Pages
- 2988-2995
- ISSN
- 1535-3893 (ISSN-L)
- 1535-3907
- OpenAlex
- W2084362806
- Cited by
- 200
- References
- 1
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pasikanti, K. K., Esuvaranathan, K., Ho, P. C., Mahendran, R., Kamaraj, R., Wu, Q. H., Chiong, E., & Chan, E. C. Y. (2010). Noninvasive Urinary Metabonomic Diagnosis of Human Bladder Cancer. Journal of Proteome Research. https://doi.org/10.1021/pr901173v
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