Inhibition of Human Mitochondrial Aldehyde Dehydrogenase by 4-Hydroxynon-2-enal and 4-Oxonon-2-enal

Doorn, Jonathan A., Hurley, Thomas D., Petersen, Dennis R.·2006·Chemical Research in Toxicology

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  2. Ethanol induces skin hyperpigmentation in mice with aldehyde dehydrogenase 2 deficiency
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  3. Aldehyde Dehydrogenase (ALDH) 2 in Diabetic Heart Diseases
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  4. Role of covalent modification by hepatic aldehydes in dictamnine-induced liver injury
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  5. Effects of 4‐Oxo‐2‐nonenal on biochemical properties of bovine heart mitochondria
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  6. Mitochondria and Alcohol-Associated Liver Disease: Pathogenic Role and Target for Therapy
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  7. Role of the Lipid Peroxidation Product, 4-Hydroxynonenal, in the Development of Nitrate Tolerance
    Yohan D’Souza, Toshihiro Kawamoto, Brian M. Bennett · 2014 · Chemical Research in Toxicology
  8. cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression
    Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E. Rowe, Lupeng Li, Laura E. Herring et al. · 2025 · Advanced Science
  9. Activator of Mitochondrial Aldehyde Dehydrogenase (Alda-1) Could Enhance Quality of Equine Cooled Semen by Ameliorating Loss of Mitochondrial Function Over Time
    Vahid Akbarinejad, Rouhollah Fathi, Abdolhossein Shahverdi, Vahid Esmaeili, Alireza Rezagholizadeh, Leila Rashki Ghaleno · 2018 · Journal of Equine Veterinary Science
  10. Comorbid alcohol use and post-traumatic stress disorders: Pharmacotherapy with aldehyde dehydrogenase 2 inhibitors versus current agents
    Claire Morice, Luba Yammine, Jin Sang Yoon, Scott D. Lane, Joy M. Schmitz, Thomas R. Kosten, Richard De La Garza, Christopher D. Verrico · 2022 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  11. LC‐MS/MS Quantitation of Mercapturic Acid Conjugates of Lipid Peroxidation Products as Markers of Oxidative Stress
    Heather C. Kuiper, Jan Frederik Stevens · 2010 · Current Protocols in Toxicology
  12. Mechanisms and preventive measures of ALDH2 in ischemia‑reperfusion injury: Ferroptosis as a novel target (Review)
    Liang Han, Wen Zhai · 2025 · Molecular Medicine Reports
  13. 4-Oxo-2-nonenal (4-ONE)-Induced Degradation of Bovine Skeletal Muscle Proteins
    Loren Klein, Dennis R. Phillips, Fanbin Kong, BRIAN C. BOWKER, Anand Mohan · 2022 · Journal of Agricultural and Food Chemistry
  14. Converging mechanisms in ethanol neurotoxicity
    Miriam B. Virgolini, Ricardo Marcos Pautassi · 2022 · Advances in neurotoxicology
  15. Catalytic contribution of threonine 244 in human ALDH2
    Lilian González‐Segura, K.-K. Ho, Samantha Perez‐Miller, Henry Weiner, Thomas D. Hurley · 2013 · Chemico-Biological Interactions
  16. Alternative, High‐Yield Synthesis of(E)‐4‐Oxonon‐2‐enoic Acid from 2‐Methoxyfuran
    Ahmet Maraş, Ahmet Altay, Roberto Ballini · 2008 · Synthetic Communications
  17. Detection of Protein Thiols in Mitochondrial Oxidative Phosphorylation Complexes and Associated Proteins
    Kelly K. Andringa, Shannon M. Bailey · 2010 · Methods in enzymology on CD-ROM/Methods in enzymology
  18. SIRT3 deacetylase: the Jekyll and Hyde sirtuin
    Dafne Magalı́ Silberman, Raúl Mostoslavsky · 2011 · EMBO Reports
  19. Lipoxidation-Derived Electrophiles as Biological Reactive Intermediates
    De Lin, Lawrence M. Sayre · 2008 · Springer eBooks
  20. Dysregulation of cardiac mitochondrial aldehyde dehydrogenase 2: Studies in dogs with chronic heart failure
    Ramesh C. Gupta, Vinita Singh‐Gupta, Kristina J. Szekely, Kefei Zhang, David E. Lanfear, Hani N. Sabbah · 2024 · Journal of Molecular and Cellular Cardiology Plus
  21. Association of Impaired Reactive Aldehyde Metabolism with Delayed Graft Function in Human Kidney Transplantation
    Leonie G.M. Wijermars, Alexander F. Schaapherder, Thomas J. George, Pritam Sinharoy, Eric Richard Gross · 2018 · Oxidative Medicine and Cellular Longevity
  22. Heavy alcohol use exacerbates skeletal myopathy in peripheral artery disease
    Panagiotis Koutakis, Emma Fletcher, Evlampia Papoutsi, William T. Bohannon, Iraklis I. Pipinos, Dimitrios Miserlis, Pál Pacher · 2025 · GeroScience
  23. The Activation of Aldehyde Dehydrogenase 2 (ALDH2) by Alda-1 and Flurbiprofen as a Common Mechanism to Reduce Alcohol Intake in Rats
    Juan Manuel Torres, Carolina A. Ponce, Vicente Pérez, Ignacio Gutiérrez-Vega, Marı́a Elena Quintanilla, David Vásquez, Mario Rivera‐Meza · 2026 · International Journal of Molecular Sciences
  24. From a computational point of view: deciphering the molecular synergism between oxidative stress-induced lipid peroxidation products and metabolic dysfunctionality of human liver mitochondrial aldehyde dehydrogenase-2
    Emmanuel A. Adeniji, Fisayo Andrew Olotu, Letitia Shunmugam, Mahmoud E. S. Soliman · 2019 · Molecular Simulation
  25. Dopamine Catabolism and Parkinson's Disease: Role of a Reactive Aldehyde Intermediate
    Jonathan A. Doorn · 2009 · Wiley eBooks
  26. Adipose Carbonylation and Mitochondrial Dysfunction
    Amy K. Hauck, Dalay H. Olson, Joel S. Burrill, David Bernlohr · 2017
  27. Participação da enzima aldeído desidrogenase 2 na insuficiência cardíaca induzida por infarto do miocárdio.
    Maria Kátia Gomes · 2014
  28. Mass Spectrometry-Based Characterization of Posttranslational Modifications by 4-Hydroxy-2-Nonenal
    Navin Rauniyar · 2010 · Digital Commons @ UNT Health Science Center
  29. Covalent modification and inhibition of tyrosine hydroxylase by 3,4-dihydroxyphenylacetaldehyde, an endogenously produced neurotoxin relevant to Parkinson's disease
    Lydia M.M. Vermeer · 2012
  30. Improving the detection of carbonylated peptides by mass spectrometry via solid-phase hydrazide enrichment and selective labeling with Oxygen-18 (18O)
    Mikel R. Roe · 2010 · University of Minnesota Digital Conservancy (University of Minnesota)
  31. CHARACTERIZATION OF PROTEIN MODIFICATION BY PRODUCTS OF LIPID PEROXIDATION
    Xiaochun Zhu · 2009 · OhioLink ETD Center (Ohio Library and Information Network)
  32. Mecanismos involucrados en el cáncer de mama por consumo de alcohol y alternativas para su prevención Mechanisms involved in breast cancer induced by alcohol drinking and alternatives for prevention Mecanismos envolvidos no câncer de mama por consumo de álcool e alternativas para sua prevenção
    Gerardo Daniel Castro, María Eugenia Maciel, Leandro Néstor Quintans, José Alberto Castro · 2015
  33. Análise da atividade e expressão da proteína Dicer em condições de estresse de aldeídos: possível papel protetor da enzima ALDH2.
    Ligia Akemi Kiyuna · 2019
  34. The role of aldehyde dehygrogenase 2 in liver injury caused by vinyl chloride and high-fat diet.
    Liya Chen · 2018
  35. New insight into Acyclovir Renal Handling and Nephrotoxicity
    Patrina Gunness · 2012 · TSpace (University of Toronto)
  36. Acetaldehyde dehydrogenase 2 (ALDH2) activation protects hepatocytes from mitochondrial damage and death caused by 4-hydroxynonenal.
    Keegan J. Baldauf · 2012
  37. Mechanisms and Preventive Measures of Aldh2 in Ischemia-Reperfusion Injury: Ferroptosis as a Novel Target
    Liang Han, Wen Zhai · 2024 · SSRN Electronic Journal
  38. Rôles du stress oxydant et de ses dérivés dans les mécanismes physiopathologiques de l’insuffisance cardiaque
    Yohan Santin · 2019 · theses.fr (ABES)
  39. Reviewing the Implication of Aldehyde Dehydrogenases in Male Reproduction: Prospects for New Therapeutic Approaches
    Foteini Gkaitatzi, Ilias Tsochantaridis, Olga Pagonopoulou, Georgia-Persephoni Voulgaridou · 2026 · Pharmaceuticals
  40. Identification and Characterization of Quinone-Thioether Protein Adducts In Vivo
    Matthew Labenski · 2008 · UA Campus Repository (The University of Arizona)