Rat α-Fetoprotein Binding Affinities of a Large Set of Structurally Diverse Chemicals Elucidated the Relationships between Structures and Binding Affinities

Hong, Huixiao; Branham, William S.; Dial, Stacey L.; Moland, Carrie L.; Fang, Hong; Shen, Jie; Perkins, Roger; Sheehan, Daniel; Tong, Weida

doi:10.1021/tx3003406

Rat α-Fetoprotein Binding Affinities of a Large Set of Structurally Diverse Chemicals Elucidated the Relationships between Structures and Binding Affinities

Endocrine disrupting chemicals interfere with the endocrine system in animals, including humans, to exert adverse effects. One of the mechanisms of endocrine disruption is through the binding of receptors such as the estrogen receptor (ER) in target cells. The concentration of any chemical in ser…