The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration
Abstract
The lymphatic absorption of four water-soluble compounds with different molecular weights (MW) was determined by measuring their cumulative recovery in lymph draining from the site of s.c. administration in sheep. The cumulative recoveries (% of dose, mean +/- SD; N = 3) were 4.0 +/- 1.5 (5-fluoro-2'-deoxyuridine, MW 246.2), 21.0 +/- 7.1 (inulin, MW 5200), 38.6 +/- 6.7 (cytochrome c, MW 12,300), and 59.5 +/- 7.7 [human recombinant interferon (rIFN) alpha-2a, MW 19,000], respectively. Our data show that in the investigated MW range, there is a linear relationship between the molecular weight and the proportion of the dose absorbed lymphatically. An increase in molecular weight results in an increased lymphatic absorption. Molecules with MW greater than 16,000 are absorbed mainly by the lymphatics which drain the application site. The knowledge gained in this investigation may help to improve the mode of administration and therapeutic efficacy of endogenous proteins whose targets are lymphoid cells (e.g., interferons, interleukins). Practical implications for the clinical use of such proteins are discussed.
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In the citing paper
“whereas the pharmacokinetic profile of subcutaneously injected therapeutic proteins is typically characterized by a slow absorption rate from the subcutaneous extracellular matrix with Cmax levels below those achieved with intravenous dosing.”
From Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities (2018) · cites this paper as [71]
In the citing paper
“This absorption pattern of macromolecules into the blood is a consequence of their limited permeability across the vascular endothelia”
From Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities (2018) · cites this paper as [71]
In the citing paper
“therefore, the lymphatics provide an alternative absorption pathway into the circulation system [70, 71].”
From Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities (2018) · cites this paper as [71]
In the citing paper
“Unlike small molecules, biotherapeutics with molecular weights of > 20 kDa exhibit limited transport into the blood capillaries and cross into the circulation system predominantly via the lymphatics [10, 71].”
From Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities (2018) · cites this paper as [71]
Citations
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Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
Wang, W., Wang, E., & Balthasar, J. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.170 · Cited by 978
From Sewer to Saviour—Targeting the Lymphatic System to Promote Drug Exposure and Activity
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Metadata
- Authors
- Supersaxo, A., Hein, W. R., & Steffen, H.
- Affiliations
- F. Hoffmann-La Roche AG (CH)
- ORCID
- Hein, Wayne R.
- Venue
- Pharmaceutical Research
- Published
- 1990-02
- Volume
- 7
- Issue
- 2
- Pages
- 167-169
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W1586699825
- Cited by
- 386
- References
- 14
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 25 · 2023: 20 · 2022: 25 · 2021: 29 · 2020: 21 · 2019: 19 · 2018: 18 · 2017: 9 · 2016: 11 · 2015: 20 · 2014: 10 · 2013: 20 · 2012: 25
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- lymphatic absorption, molecular weight, subcutaneous administration, water-soluble compounds, lymphatic drainage, 5-fluorodeoxyuridine, inulin, cytochrome c, interferon alfa-2a, sheep, lymphatic drug delivery
- MeSH terms
- Absorption, Animals, Chemistry, Physical, Female, Floxuridine, Injections, Subcutaneous, Insulin, Interferon Type I, Lymphatic System, Male, Molecular Weight, Recombinant Proteins, Sheep, Solubility, Chemical Phenomena
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- CoChat. (2026). Citation check: Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration. https://app.cochat.ai/papers/10.1023/a:1015880819328
- The paper
- Supersaxo, A., Hein, W. R., & Steffen, H. (1990). Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration. Pharmaceutical Research. https://doi.org/10.1023/a%3A1015880819328
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
