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Clinical Assisted Reproduction: High FSH:LH Ratio and Low LH Levels in Basal Cycle Day 3: Impact on Follicular Development and IVF Outcome
Open accessAbstract
Purpose To examine the impact of low basal cycle day 3 serum LH levels or a high FSH:LH ratio on IVF results. Methods A homogeneous group of patients was analyzed as identified by normal basal cycle of follicle stimulating hormone (FSH), Luteinizing hormone (LH), and estradiol (E2) levels. High responders (high LH:FSH ratio) and low responders (high FSH or E2 levels, and women > or = 42 years of age) were excluded from analysis. Only cycles stimulated with a combination of a GnRHa (luteal suppression) and pure FSH were studied. Results Patients with low basal LH levels (< 3 mIU/mL) did not differ significantly from controls in terms of response to controlled ovarian hyperstimulation but there was a clear trend toward poorer implantation and clinical pregnancy rates. On the other hand, patients with a high FSH:LH ratio (> 3) had significantly fewer mature oocytes aspirated, and lower implantation and clinical pregnancy rates than patients with gonadotropin ratio < or = 3. These negative effects were evident in the presence of normal basal FSH levels and after adequate matching of female's age and number of embryos transferred. Conclusions These studies highlight a negative impact of a basal cycle high FSH:LH ratio (and possibly low LH levels) on follicular development and oocyte quality in these patients subjected to pituitary down-regulation followed by pure FSH administration. A high FSH:LH ratio may be therefore used as an early biomarker of poor ovarian response.
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A basal cycle high FSH:LH ratio (and possibly low LH levels) has a negative impact on follicular development and oocyte quality.
“Other studies have highlighted a negative impact of a basal cycle high FSH:LH ratio (and possibly low LH levels) on follicular development and oocyte quality [33].”
From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [33]
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Research works printed but not linked: 23
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Stress and the HPA Axis: Balancing Homeostasis and Fertility.
Joseph, D., & Whirledge, S. (2017) · International journal of molecular sciences · doi:10.3390/ijms18102224 · Cited by 290
“Other studies have highlighted a negative impact of a basal cycle high FSH:LH ratio (and possibly low LH levels) on follicular development and oocyte quality [33].”
Background
Metadata
- Authors
- Barroso, G., Oehninger, S., Monzó, A., Kolm, P., Gibbons, W. E., & Muasher, S. J.
- Affiliations
- Eastern Virginia Medical School (US)
- Corresponding author
- Oehninger, Sergio
- Venue
- Journal of Assisted Reproduction and Genetics
- Published
- 2001-09
- Volume
- 18
- Issue
- 9
- Pages
- 499-505
- ISSN
- 0740-7769 (ISSN-L)
- 1058-0468
- 1573-7330
- PMC
- PMC3455729
- OpenAlex
- W1553563204
- Cited by
- 56
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Assisted Reproduction and Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- FSH/LH ratio, luteinizing hormone, folliculogenesis, oocyte quality, IVF outcomes, implantation rate, clinical pregnancy rate, GnRH agonist down-regulation, poor ovarian response, biomarkers, estradiol
- MeSH terms
- Adult, Female, Follicle Stimulating Hormone, Ovarian Follicle, Humans, Luteinizing Hormone, Ovulation Induction, Pregnancy, Retrospective Studies, Treatment Outcome, Pregnancy Rate
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