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A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies
Abstract
The purpose of these studies was to develop a metastatic osteosarcoma nude mouse model to evaluate the in vivo efficacy of new therapeutic compounds. Human SAOS-2 osteosarcoma cells (10(6) cells) were injected i.v. into nude mice. Cells isolated from a rare pulmonary metastases 6 months later were established (SAOS-LM1) in culture and re-injected. This procedure was repeated 5 additional times to produce the SAOS-LM6 cell line. Visible pulmonary nodules were present 8 weeks following i.v. injection of 10(6) SAOS-LM6 cells as compared to 17 weeks using SAOS-LM2 cells. Microscopic SAOS-LM6 pulmonary metastases were demonstrated at 6 weeks. Administration of adriamycin on week 9 resulted in regression of macroscopic SAOS-LM6 lung tumors. The ability of the model to be used to evaluate the effectiveness of a biologic agent against microscopic disease was also verified. It was concluded that this model can assess therapeutic efficacy and therefore, may have a role in investigating the potential of novel approaches aimed at eliminating pulmonary metastatic osteosarcoma.
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“Companion cell lines with enhanced lung colonization capacity, such as SaOS2-LM7, MG63.3 and 143B 209,210,211 , have enabled the study of metastasis-driving mechanisms 50,212 .”
From Osteosarcoma (2022) · cites this paper as [209]
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Cites
Selection of Successive Tumour Lines for Metastasis
Fidler, I. J. (1973) · Nature New Biology · doi:10.1038/newbio242148a0 · Cited by 1,365
Link, M. P., Goorin, A. M., Miser, A. W., Green, A. A., Pratt, C. B., Belasco, J. B., Pritchard, J., Malpas, J. S., Baker, A. R., Kirkpatrick, J. A., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606193142502 · Cited by 1,203
Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial.
Eilber, F. R., Giuliano, A. E., Eckardt, J. J., Patterson, K., Moseley, S. H., & Goodnight, J. E. (1987) · Journal of Clinical Oncology · doi:10.1200/jco.1987.5.1.21 · Cited by 524
Morikawa, K., Walker, S. M., Nakajima, M., Pathak, S., Jessup, J. M., & Fidler, I. J. (1988) · PubMed · Cited by 474
Giavazzi, R., Campbell, D., Jessup, J. M., Cleary, K. R., & Fidler, I. J. (1986) · PubMed · Cited by 239
Putnam, J. B., Roth, J. A., Wesley, M. N., Johnston, M. R., & Rosenberg, S. A. (1983) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)60679-0 · Cited by 179
Berlin, Ö., Samid, D., Donthineni-Rao, R., Akeson, W. H., Amiel, D., & Woods, V. L. (1993) · PubMed · Cited by 150
Goorin, A. M., Shuster, J. J., Baker, A., Horowitz, M. E., Meyer, W. H., & Link, M. (1991) · Journal of Clinical Oncology · doi:10.1200/jco.1991.9.4.600 · Cited by 134
Efficacy of Liposomal Muramyl Tripeptide (CGP 19835A) in the Treatment of Relapsed Osteosarcoma
Kleinerman, E. S., Gano, J. B., Johnston, D. A., Benjamin, R. S., & Jaffe, N. (1995) · American Journal of Clinical Oncology · doi:10.1097/00000421-199504000-00001 · Cited by 116
Self-citationChen, D. S., Zhu, N., Hung, G., Skotzko, M. J., Hinton, D. R., Tolo, V. T., Hall, F. L., Anderson, W. F., & Gordon, E. M. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.14-1667 · Cited by 50
Timing of chemotherapy and surgery in a murine osteosarcoma model.
Bell, R. S., Roth, Y. F., Gebhardt, M. C., Bell, D. F., Rosenberg, A. E., Mankin, H. J., & Suit, H. D. (1988) · PubMed · Cited by 44
Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man
Cobb, L. (1970) · British Journal of Cancer · doi:10.1038/bjc.1970.34 · Cited by 36
Development and characterization of pediatric osteosarcoma xenografts.
Meyer, W. H., Houghton, J. A., Houghton, P. J., Webber, B. L., Douglass, E. C., & Look, A. T. (1990) · PubMed · Cited by 29
Hudson, M. M., Snyder, J. S., Jaffe, N., & Kleinerman, E. S. (1988) · PubMed · Cited by 28
Self-citationVirus-induced animal model of osteosarcoma in the rat: Morphologic and biochemical studies.
Olson, H. M., & Capen, C. C. (1977) · PubMed Central · Cited by 20
Killion, J. J., Kleinerman, E. S., Wilson, M. R., Tanaka, M., & Fidler, I. J. (1992) · PubMed · Cited by 19
Self-citationInterferon-alpha Enhances the Sensitivity of Human Osteosarcoma Cells to Etoposide
Jia, S.-F., An, T., Worth, L. L., & Kleinerman, E. S. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313758 · Cited by 14
Self-citationBone tumours induced in rats with radioactive cerium
Delbrück, H., Allouche, M., Jasmin, C., Morin, M., Deml, F., Anghileri, L. J., Masse, R. S., & Lafuma, J. (1980) · British Journal of Cancer · doi:10.1038/bjc.1980.145 · Cited by 12
The biology, pathology and immunology of a virus induced rat osteosarcoma
Czitrom, A. A., Langer, F., Gross, A. E., UROVITZ, E. P. M., & Pritzker, K. P. H. (1980) · International Orthopaedics · doi:10.1007/bf00268152 · Cited by 3
An experimental osteosarcoma of the athymic nude rat.
WITZEL, J. G., & Prescher, A. (1991) · PubMed · Cited by 3
Research works printed but not linked: 5
- Jaffe N. Chemotherapy in osteosarcoma: Experimental and clinical progress in cancer chemotherapy. In Muggia FM(ed): Advances and Controversies. Boston: Martinus Nijhoff Publishers 1986; 223–33.
- Jia SF, Zwelling LA, McWatters A, ANT, Kleinerman ES. Interleukin-1? increase the cytotoxicity activity of etoposide against human osteosarcoma cells. J Exp Therap & Oncol (in press).
- Jia SF, Fan D, Kleinerman ES. Synergestic enhancement of adriamycin cytotoxicity against human osteosarcoma cells by TNFα. Pro Am Assoc Cancer Res 1992; 33: 3301.
- Samid D, Mandler R. Human osteosarcoma cells transformed by ras oncogenes: a new model for in vivo studies of pulmonary metastasis. Clinic Biotechnol 1989; 1: 21–6.
- Olson HM, Capen CC. Virus-induced animal model of osteosarcoma in the rat. Am J Pathol 1977; 86: 437–52.
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Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
Basu-Roy, U., Bayin, N. S., Rattanakorn, K., Han, E. J., Placantonakis, D. G., Mansukhani, A., & Basilico, C. (2015) · Nature Communications · doi:10.1038/ncomms7411 · Cited by 257
Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas
Basu-Roy, U., Seo, E., Ramanathapuram, L. V., Rapp, T. B., Perry, J. A., Orkin, S. H., Mansukhani, A., & Basilico, C. (2011) · Oncogene · doi:10.1038/onc.2011.405 · Cited by 239
An Orthotopic Model of Human Osteosarcoma Growth and Spontaneous Pulmonary Metastasis
Luu, H. H., Kang, Q., Park, J. K., Si, W., Luo, Q., Jiang, W., Yin, H. X., MONTAG, A. G., Simon, M. A., Peabody, T. D., et al. (2005) · Clinical & Experimental Metastasis · doi:10.1007/s10585-005-0365-9 · Cited by 237
Ahmed, N., Salsman, V. S., Yvon, E., Louis, C. U., Perlaky, L., Wels, W. S., Dishop, M. K., Kleinerman, E. E., Pule, M., Rooney, C. M., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.133 · Cited by 215
Self-citation
Metadata
- Authors
- Jia, S.-F., Worth, L. L., & Kleinerman, E. S.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Venue
- Clinical & Experimental Metastasis
- Published
- 1999-10
- Volume
- 17
- Issue
- 6
- Pages
- 501-506
- ISSN
- 0262-0898 (ISSN-L)
- 1573-7276
- OpenAlex
- W186831022
- Cited by
- 146
- References
- 20
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 8
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Clinical & Experimental Metastasis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA-42992, CA-16672, R01CA042992, P30CA016672)
- Topics
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- osteosarcoma, lung metastasis, nude mouse model, Saos-2 cells, doxorubicin, treatment efficacy assessment, biologic agents
- MeSH terms
- Animals, Antineoplastic Agents, Disease Models, Animal, Doxorubicin, Drug Screening Assays, Antitumor, Etoposide, Humans, Lung Neoplasms, Mice, Nude, Neoplasm Transplantation, Osteosarcoma, Vinblastine, Cytokines, Mice
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