The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Clay catalysis of oligonucleotide formation: kinetics of the reaction of the 5′-phosphorimidazolides of nucleotides with the non-basic heterocycles uracil and hypoxanthine
Open accessAbstract
The montmorillonite clay catalyzed condensation of activated monocleotides to oligomers of RNA is a possible first step in the formation of the proposed RNA world. The rate constants for the condensation of the phosphorimidazolide of adenosine were measured previously and these studies have been extended to the phosphorimidazolides of inosine and uridine in the present work to determine of substitution of neutral heterocycles for the basic adenine ring changes the reaction rate or regioselectivity. The oligomerization reactions of the 5'-phosphoromidazolides of uridine (ImpU) and inosine (ImpI) on montmorillonite yield oligo(U)s and oligo(I)s as long as heptamers. The rate constants for oligonucleotide formation were determined by measuring the rates of formation of the oligomers by HPLC. Both the apparent rate constants in the reaction mixture and the rate constants on the clay surface were calculated using the partition coefficients of the oligomers between the aqueous and clay phases. The rate constants for trimer formation are much greater than those dimer synthesis but there was little difference in the rate constants for the formation of trimers and higher oligomers. The overall rates of oligomerization of the phosphorimidazolides of purine and pyrimidine nucleosides in the presence of montmorillonite clay are the same suggesting that RNA formed on the primitive Earth could have contained a variety of heterocyclic bases. The rate constants for oligomerization of pyrimidine nucleotides on the clay surface are significantly higher than those of purine nucleotides since the pyrimidine nucleotides bind less strongly to the clay than do the purine nucleotides. The differences in the binding is probably due to Van der Waals interactions between the purine bases and the clay surface. Differences in the basicity of the heterocyclic ring in the nucleotide have little effect on the oligomerization process.
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“Second, the rate at which different monomers are polymerized can vary by an order of magnitude (6,17–20).”
From Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences (2012) · cites this paper as [17]
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Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Robertson, M. P., & Joyce, G. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003608 · Cited by 556
Origins of building blocks of life: A review
Kitadai, N., & Maruyama, S. (2018) · Geoscience Frontiers · doi:10.1016/j.gsf.2017.07.007 · Cited by 464
Ferris, J. P. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1903 · Cited by 253
Self-citationChemistry of Abiotic Nucleotide Synthesis
Yadav, M., Kumar, R., & Krishnamurthy, R. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00546 · Cited by 225
Metadata
- Authors
- Kawamura, K., & Ferris, J. P.
- Affiliations
- Osaka Prefecture University (JP)
- Rensselaer Polytechnic Institute (US)
- ORCID
- Kawamura, Kunio
- Venue
- Origins of life and evolution of the biosphere
- Published
- 1999-12
- Volume
- 29
- Issue
- 6
- Pages
- 563-591
- ISSN
- 0169-6149 (ISSN-L)
- 1573-0875
- OpenAlex
- W1552616832
- Cited by
- 61
- References
- 46
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 3
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Origins of Life and Evolution of Biospheres (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- clay catalysis, montmorillonite, RNA world, uracil, hypoxanthine, oligomerization kinetics, pyrimidine nucleotides, purine nucleotides, RNA primers
- MeSH terms
- Clay, Aluminum Silicates, Catalysis, Imidazoles, Kinetics, Nucleotides, Oligonucleotides, Organophosphates, Uracil, Hypoxanthine
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