CoChat
Sign Up
Cited by 26Cholesterol and Lipid MetabolismEstrogen and related hormone effectsLipoproteins and Cardiovascular Health

The DOI matches its Crossref record.

Regulation of lipoprotein metabolism by estrogen in inbred strains of mice occurs primarily by posttranscriptional mechanisms

Srivastava, Rai Ajit K., Krul, Elaine S., Lin, Renee C., Schonfeld, Gustav·1997·Molecular and Cellular Biochemistry
DOI 10.1023/a:1006896131186
Open this paper in CoChat — free account

Abstract

Estrogen protects against developing premature coronary artery disease. However, the mechanism of protective effects of estrogen still remains poorly understood. One mechanism by which estrogen can have protective effects appears to be through modulation of plasma lipoproteins. We showed that the mouse can be used as animal model to study estrogen-mediated synthesis and secretion of lipoproteins since, unlike the rat, the mouse does not up-regulate LDL receptors (Srivastava et al. [4]). Since inbred strains of mice differ in their genetic background and show differing responsiveness to dietary lipids, we examined how various inbred strains of mice respond to estradiol administration, and whether some mouse strains show responses similar to rats. 17beta-estradiol was administered to male mice from 15 different inbred strains, and the changes in plasma levels of lipids, apoB, apoAI, and apoE were examined. Total cholesterol decreased in all but one strain, apoAI levels decreased in all but 3 strains while apoB levels and apoB/apoAI ratios increased in all but 2 strains, suggesting that in contrast to rats, the apoB-containing lipoproteins increased relative to HDL in all strains of mice examined. Basal and estradiol-induced changes in total cholesterol were significantly correlated with changes in apoAI, but not apoB, reflecting the predominance of HDL over other lipoproteins in mouse plasma. The effects of estrogen on plasma apoE levels varied among various inbred strains of m…

Overview

Integrity signals

Registry

Crossref · 10.1023/a:1006896131186

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 31

  1. Kannel WB, Hjiortland MC, McNamara PM, Gordon T: Menopause and risk of cardiovascular disease: The Framingham study. Ann Intern Med 85: 447–452, 1976 · DOI
  2. Kushwaha RP, Lewis DS, Carey KD, McGill HC Jr: Effects of estrogen and progesterone on plasma lipoproteins and experimental atherosclerosis in the baboon. Metabolism. 11: 23–31, 1991
  3. Wagner JD, Clarkson TB, St Clair RW, Schwenke DC, Shiverly CA, Adams MR: Estrogen and progesterone therapy reduces low-density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys. J Clin Invest 88: 1995–2002, 1991 · DOI
  4. Srivastava RAK, Baumann D, Schonfeld G: In vivoregulation of low density lipoprotein receptors by estrogen differs at the posttranscriptional levels in rat and mouse. Eur J Biochem 216: 527–538, 1993 · DOI
  5. Srivastava RAK, Kitchens RT, Schonfeld G: Regulation of the apolipoprotein AIV gene expression by estrogen differs in rat and mouse. Eur J Biochem 222: 507–514, 1994 · DOI
  6. Srivastava RAK, Jiao S, Tang J, Pfleger B, Kitchens RT, Schonfeld G: In vivoregulation of low density lipoprotein receptor and apolipoprotein B gene expression by dietary fat and cholesterol in inbred strains of mice. Biochim Biophys Acta 1086: 2943, 1991
  7. Yang CY, Chan SH, Gianturco SH, Bradely WA, Sparrow JT, Tanimura M, Li WH, Sparrow DA, DeLoof H, Rosseneu M, Lee FS, Gu ZW, Gotto AM Jr, Chan L: Sequence, structure, receptor binding domains and internal repeats of human apolipoprotein B-100. Nature 323: 738–742, 1986 · DOI
  8. Glickman RM, Rogers M, Glickman JM: Apolipoprotein B synthesis by human liver and intestine in vitro. Proc Natl Acad Sci USA 83: 5296–5300, 1986 · DOI
  9. Lock DR, Hockenberry D, Cunningham J, Hahm KS, Kantor O, Schonfeld G: Apolipoprotein B subspecies in chylomicrons isolated from a patient with chyluria. Am J Med 75: 360–364, 1983 · DOI
  10. Kane JP, Sata T, Hamilton RL, Havel RJ: Apoprotein composition of very low density lipoproteins of human serum. J Clin Invest 56: 1622–1634, 1975 · DOI
  11. Elovson J, Huang YO, Baker N, Kannan R: Apolipoprotein B is structurally and metabolically heterogeneous in the rat. Proc Natl Acad Sci USA 78: 157–161, 1981 · DOI
  12. Pullinger CR, North JD, Teng B-B, Rifici VA, Ronhild de Brito AE, Scott J: The apolipoprotein B gene is constitutively expressed in HepG2 cells: Regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life. J Lipid Res 30: 1065–1077, 1989 · DOI
  13. Moberly JB, Cole TG, Alpers DH, Schonfeld G: Oleic acid stimulation of apolipoprotein B secretion from HepG2 and Caco-2 cells occurs post-transcriptionally. Biochim Biophys Acta 1042: 70–80, 1990 · DOI
  14. Dixon JL, Furukawa S, Ginsberg HN: Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from HepG2 cells by inhibiting early intracellular degradation of apolipoprotein B. J Biol Chem 266: 5080–5086, 1991 · DOI
  15. Srivastava RAK, Tang J, Baumann D, Schonfeld G: Hormonal and nutritional stimuli modulate apolipoprotein B mRNA editing in mouse liver. Biochem. Biophys Res Commun 188: 135–141, 1992 · DOI
  16. Shimano H., Yamada N, Katsuki M, Shimada M, Gotoda T, Harada K, Murase T, Fukazawa T, Yazaki Y: Proc Natl Acad Sci USA, 89: 1750–1754, 1992 · DOI
  17. Zhang SH, Reddick RL, Pierdrahita JA, Maeda N: Science 258: 468–471, 1992 · DOI · Paper page
  18. Srivastava RAK, Srivastava N, Schonfeld G: Expression of low density lipoprotein receptor, apolipoprotein AI, apolipoprotein AII and apolipoprotein AIV in various rat organs utilizing an efficient method for RNA isolation. Biochem Intern 27: 85–95, 1992
  19. Lin RC: Quantification of apolipoproteins in rat serum and in culture red rat hepatocytes by enzyme-linked immunosorbent assay. Anal Biochem 154: 316–326, 1986 · DOI
  20. Srivastava RAK, Tang J, Krul ES, Pfleger B, Kitchens RT, Schonfeld G: Dietary fatty acids and dietary cholesterol differ in their effects on the in vivoregulation of apolipoprotein AI and apolipoprotein AII gene expression in inbred strains of mice. Biochim Biophys Acta 1125: 251–261, 1992 · DOI
  21. Srivastava RAK, Pfleger B, Schonfeld G: Expression of LDL-receptor, apolipoprotein B, apolipoprotein AI and apolipoprotein AIV mRNA in various mouse organs as determined by a novel solution hybridization assay. Biochim Biophys Acta 1090: 95–101, 1991 · DOI
  22. Srivastava RAK, Schonfeld G: Using riboprobes for Northern blot analysis. Bio/Techniques 11: 584–587, 1991
  23. Srivastava RAK: Regulation of the apolipoprotein E by dietary lipids occurs by transcriptional and posttranscriptional mechanisms. Mol Cell Biochem 155: 153–162, 1996
  24. Linton MF, Babaev VR, Gleaves LA, Atkinson JB, Fazio S: Increased atherosclerosis in C57BL/6 mice transplanted with apolipoprotein E deficient marrow. Circulation pplement 94: 2313, 1996
  25. Bellosta S, Mahley RW, Sanan DA, Murata J, Newland DL, Taylor JM, Pitas RE: J Clin Invest 96: 2170–2179, 1995 · DOI · Paper page
  26. Zhang W-Y, Gaynor PM, Kruth HS: Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors. J Biol Chem 271: 28641–28646, 1996 · DOI
  27. Staels B, Auwerx J, Chan L, Tol AV, Rosseneu M, Verhoeven G: Influence of development, estrogens, and food intake on apolipoprotein AI, AII and E mRNA in rat river and intestine. J Lipid Res 30: 1137–1145, 1989 · DOI
  28. Meinstein I, Turner FC, Soler-Argilaga C, Heimberg M: Effect of ethinyl estradiol on serum lipoprotein lipids in male and female rats. Biochim Biophys Acta 530: 394–401, 1978 · DOI
  29. Schaefer EJ, Foster DM, Zech LA, Lindgren FT, Brewer HB Jr, Levy RI: The effects of estrogen administration on plasma lipoprotein metabolism in premenopausal females. J Endocrinol Metab 57: 262–277, 1983 · DOI
  30. Campos H, Sacks FM, Walsh BW, Schiff I, O'Hanesian MA, Krauss RM: Differential effects of estrogen on low density lipoprotein subclasses in healthy postmenopausal women. Metabolism 42: 1153–1158, 1993 · DOI
  31. Granfone A, Campos H, McNamara HR, Schaefer MM, Lamon-Fava S, Ordovas JM, Schaefer EJ: Effects of estrogen replacement on plasma lipoproteins and apolipoproteins in postmenopausal, dyslipidemic women. Metabolism 41: 1193–1198, 1992 · DOI

Cited by

Sorted by citations

Metadata

Authors
Srivastava, R. A. K., Krul, E. S., Lin, R. C., & Schonfeld, G.
Affiliations
Washington University in St. Louis (US)
ORCID
Venue
Molecular and Cellular Biochemistry
Publisher
Springer Science and Business Media LLC
Published
1997-08
Volume
173
Issue
1-2
Pages
161-168
ISSN
  • 0300-8177 (ISSN-L)
  • 1573-4919
DOI
10.1023/a:1006896131186
OpenAlex
W164958898
Cited by
26
References
0
Citations by year
2023: 1 · 2019: 1 · 2018: 1 · 2015: 1 · 2012: 1
FWCI
1.92
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular and Cellular Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p60dk020579-35)
  • National Heart, Lung, and Blood Institute (2RO1HL4246006)
  • National Institute of Diabetes and Digestive and Kidney Diseases (5P60 DK20579)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
estrogen, estradiol, lipoprotein metabolism, inbred mouse strains, post-transcriptional regulation, apolipoprotein A-I, apolipoprotein B, apolipoprotein E, hepatic mRNA, serum cholesterol, HDL cholesterol, low-density lipoprotein, genetic strain differences
MeSH terms
Animals, Apolipoproteins B, Apolipoproteins E, Apoproteins, Cholesterol, Estradiol, Estrogens, Lipids, Lipoproteins, Lipoproteins, HDL, Male, Mice, Inbred Strains, RNA Processing, Post-Transcriptional, RNA, Messenger, Apolipoprotein A-I, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review