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Application of a Biomagnetic Measurement System (BMS) to the Evaluation of Gastrointestinal Transit of Intestinal Pressure-Controlled Colon Delivery Capsules (PCDCs) in Human Subjects

Hu, Zhaopeng, Mawatari, Shunsuke, Shibata, Nobuhito, Takada, Kanji, Yoshikawa, Hiroshi, Arakawa, Akira, Yosida, Yoshikazu·2000·Pharmaceutical Research
DOI 10.1023/a:1007561129221
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Abstract

Purpose For determination of the transit time through various parts of the gastrointestinal (GI) tract, we developed a method that provides the location of disintegration and drug release. This method involves GI magnetomarkergraphy (GIMG) using a 129-channel Shimadzu vector biomagnetic measurement system (BMS). Methods To magnetically label the pressure-controlled colon delivery capsule (PCDC) containing 75.0 +/- 0.5 mg of caffeine as a tracer drug, small capsule caps containing 90 mg of ferric oxide powdered magnetite (Fe2O3) were attached to PCDCs. After orally administration to fasted human volunteers, saliva samples were collected hourly and salivary caffeine concentration was measured. At the same time, locations of the magnetic PCDC were detected by BMS just after the PCDCs were magnetized with the coils of a magnetic resonance imaging (MRI) system. The magnetic field distributions were analyzed and the estimated positions were shown on the MRI picture of the same subject's abdominal structure. Results We magnetized PCDC with permanent magnets or an electromagnet before ingestion and the estimated locations of PCDC in the GI tract exhibited high estimation error. In order to increase the precision of estimated localization of PCDCs, PCDCs were magnetized within the coils of the MRI. As a result, these PCDCs had strong magnetic dipoles that were parallel to the sensor unit of BMS in every measurement, and therefore the spatial resolution of the PCDC's two-dimensional po…

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Metadata

Authors
Hu, Z., Mawatari, S., Shibata, N., Takada, K., Yoshikawa, H., Arakawa, A., & Yosida, Y.
Venue
Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Published
2000-02
Volume
17
Issue
2
Pages
160-167
ISSN
  • 0724-8741
  • 1573-904X
DOI
10.1023/a:1007561129221
Cited by
39
References
1
Language
en
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CoChat. (2026). Citation check: Application of a Biomagnetic Measurement System (BMS) to the Evaluation of Gastrointestinal Transit of Intestinal Pressure-Controlled Colon Delivery Capsules (PCDCs) in Human Subjects. https://app.cochat.ai/papers/10.1023/a:1007561129221
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Hu, Z., Mawatari, S., Shibata, N., Takada, K., Yoshikawa, H., Arakawa, A., & Yosida, Y. (2000). Application of a Biomagnetic Measurement System (BMS) to the Evaluation of Gastrointestinal Transit of Intestinal Pressure-Controlled Colon Delivery Capsules (PCDCs) in Human Subjects. Pharmaceutical Research. https://doi.org/10.1023/a%3A1007561129221