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Cited by 224Menopause: Health Impacts and TreatmentsCancer survivorship and careSexual function and dysfunction studies

The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.

A pilot trial assessing the efficacy of paroxetine hydrochloride (Paxil) in controlling hot flashes in breast cancer survivors.

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Stearns, V., Isaacs, C., Rowland, J., Crawford, J., Ellis, M.J., Kramer, R., Lawrence, W., Hanfelt, J.J., Hayes, D.F.·2000·Annals of Oncology
DOI 10.1023/a:1008382706068
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Abstract

Background Many breast cancer survivors suffer debilitating hot flashes. Estrogen, the drug of choice in perimenopausal women, is generally not recommenced to breast cancer survivors. Nonhormonal treatments are mostly disappointing. Anecdotal reports in our institution suggested that the selective serotonin-reuptake inhibitor, paroxetine hydrochloride, might be efficacious in alleviating hot flashes. Patients and methods Thirty women with prior breast cancer who were suffering at least two hot flashes a day entered a single institution pilot trial to evaluate paroxetine's efficacy in reducing the frequency and severity of hot flashes. After completing daily diaries for one week on no therapy, the women received open-label paroxetine, 10 mg daily for one week, followed by four weeks of paroxetine, 20 mg daily. The women completed hot-flash daily diaries throughout the study period, and a health-related symptom-assessment questionnaire and a quality-of-life rating scale in the first and sixth week of the study. Results Twenty-seven women completed the six-week study period. The mean reduction of hot flash frequency was 67% (95% confidence interval (95% CI): 56%-79%). The mean reduction in hot flash severity score was 75% (95% CI: 66%-85%). There was a statistically significant improvement in depression, sleep, anxiety, and quality of life scores. Furthermore, 25 (83%) of the study participants chose to continue paroxetine therapy at the end of study. The most common adverse eff…

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Research works printed but not linked: 1

  1. 1999, Clinical synthesis panel on HRT [published erratum appears in Lancet 1999; 354 (9181): 870], Lancet, 354, 152

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Metadata

Authors
Stearns, V., Isaacs, C., Rowland, J., Crawford, J., Ellis, M. J., Kramer, R., Lawrence, W., Hanfelt, J. J., & Hayes, D. F.
Affiliations
Georgetown University (US)
ORCID
Venue
Annals of Oncology
Publisher
Elsevier BV
Published
2000-01
Volume
11
Issue
1
Pages
17-22
ISSN
0923-7534 (ISSN-L)
DOI
10.1023/a:1008382706068
OpenAlex
W2111093019
Cited by
224
References
19
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 9 · 2013: 6 · 2012: 7
FWCI
16.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Annals of Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fashion Footwear Association of New York
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Keywords
paroxetine, hot flashes, breast cancer survivors, selective serotonin reuptake inhibitors, menopausal symptoms, non-hormonal therapy, quality of life, depression, sleep, anxiety, sleepiness
MeSH terms
Adult, Aged, Anxiety, Breast Neoplasms, Depression, Female, Humans, Menopause, Middle Aged, Pilot Projects, Quality of Life, Surveys and Questionnaires, Sexual Behavior, Confidence Intervals, Selective Serotonin Reuptake Inhibitors, Paroxetine, Survivors, Hot Flashes

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