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Cited by 143Pancreatic and Hepatic Oncology ResearchMetabolism, Diabetes, and CancerCancer Risks and Factors

The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.

Diabetes mellitus and pancreaticcancer mortality in a prospectivecohort of United States adults

Calle, Eugenia E., Murphy, Terrell K., Rodriguez, Carmen, Thun, Michael J., Heath, Clark W.·1998·Cancer Causes & Control
DOI 10.1023/a:1008819701485
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Abstract

Objectives Diabetes mellitus and pancreatic cancer are known to be associated, but it is not known whether diabetes is a true risk factor, preceding development of the cancer, or if it is an early manifestation of the cancer. To address this uncertainty, we examined the association of pancreatic cancer mortality and reported diabetes of at least one year's duration in a large, prospective study of United States adults. The vast majority of diabetes in this cohort is likely to be non-insulin-dependent diabetes.Methods After 12 years of follow-up, 2,953 deaths from pancreatic cancer were observed in a cohort of 1,089,586 men and women who were cancer-free at study entry in 1982. Cox proportional hazards models, adjusted for age, race, smoking, family history of pancreatic cancer, body mass index (wt/ht2), and education, were used to assess associations.Results A history of diabetes was significantly related to pancreatic cancer mortality in both men (rate ratio [RR] = 1.49, 95 percent confidence interval [CI] = 1.25-1.77) and women (RR = 1.51, CI = 1.24-1.85). However, the strength of the association varied over the follow-up period. The death rate from pancreatic cancer was twice as high in diabetics as in non-diabetics during the second and third years of follow-up (adjusted RR = 2.05, CI = 1.56-2.69) but only about 40 percent higher in years nine to 12 (adjusted RR = 1.38, CI = 1.08-1.77).Conclusions The small but persistent increased risk of death from pancreatic cancer, seen even when the diagnosis of diabetes preceded death by many years, supports the hypothesis that diabetes may be a true, albeit modest, risk factor for pancreatic cancer.

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Research works printed but not linked: 4

  1. World Health Organization. International Classification of Diseases. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death. Vol. 1. Ninth Revision. Geneva, Switzerland: World Health Organization, 1977.
  2. Rothman KJ. Modern Epidemiology. Boston, MA (USA): Little, Brown, 1986.
  3. Kleinbaum DG, Kupper LL, Morgenstern H. Epidemiologic Research: Principles and Quantatitive Methods. New York, NY (USA): Van Nostrad Reinhold Company, 1982.
  4. Fisher WE, Boros LG, Schirmer WJ. Insulin promotes pancreatic cancer: evidence for endocrine influence on exocrine pancreatic terms. J Surg Res 1996; 63: 310–3. · DOI

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Metadata

Authors
Calle, E. E., Murphy, T. K., Rodriguez, C., Thun, M. J., & Heath, C. W.
Affiliations
American Cancer Society (US)
ORCID
Calle, Eugenia E.
Venue
Cancer Causes & Control
Publisher
Springer Science and Business Media LLC
Published
1998-08
Volume
9
Issue
4
Pages
403-410
ISSN
  • 0957-5243 (ISSN-L)
  • 1573-7225
DOI
10.1023/a:1008819701485
OpenAlex
W2573750488
Cited by
143
References
39
Citations by year
2024: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 3
FWCI
1.75
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cancer Causes & Control (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
diabetes mellitus, pancreatic cancer, pancreatic cancer mortality, type 2 diabetes, cancer risk factors, temporal association, prospective cohort
MeSH terms
Adult, Aged, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Prospective Studies, Risk Factors, United States, Cohort Studies, Comorbidity, Incidence, Survival Rate, Confidence Intervals, Proportional Hazards Models, Age Distribution, Sex Distribution

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