The use of interferon for emergency prophylaxis of Marburg hemorrhagic fever in monkeys
Abstract
The possibility of emergency prophylaxis of Marburg hemorrhagic fever with leukocytic and recombinant interferons was studied in experiments on Cercopithecus aethiops. None of the agents protected monkeys from the action of lethal doses of Marburg virus. Recombinant interferon-alpha(2)administered according to the emergency prophylaxis schedule prolonged the mean life-span of monkeys injected with Marburg virus in doses of 100 and 1000 LD50 by 1.9 and 6.1 days, respectively.
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Marburg virus disease outbreaks, mathematical models, and disease parameters: a systematic review
Cuomo-Dannenburg, G., McCain, K., McCabe, R., Unwin, H. J. T., Doohan, P., Nash, R. K., Hicks, J. T., Charniga, K., Geismar, C., Lambert, B., et al. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(23)00515-7 · Cited by 59 · see citing works
“The two generation time estimates were based on viral load data from non-human primates under two distinct assumptions, namely that infectiousness is directly proportional to viral load, and alternatively assuming that probability of death is directly proportional to viral load (24,29).”
Transmission Potential and Design of Adequate Control Measures for Marburg Hemorrhagic Fever
Ajelli, M., & Merler, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050948 · Cited by 44 · see citing works
- Authors
- Kolokol'tsov, A. A., Davidovich, I. A., Strel'tsova, M. A., Nesterov, A. E., Agafonova, O. A., & Agafonov, A. P.
- Affiliations
- State Research Center of Virology and Biotechnology VECTOR (RU)
- Venue
- Bulletin of Experimental Biology and Medicine
- Published
- 2001-07
- Volume
- 132
- Issue
- 1
- Pages
- 686-688
- ISSN
- 0007-4888 (ISSN-L)
- 1573-8221
- OpenAlex
- W50735278
- Cited by
- 14
- References
- 0
- Citations by year
- 2025: 1 · 2023: 2 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Bulletin of Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- Marburg hemorrhagic fever, Marburg virus, interferon, vervet monkey, survival prolongation, antiviral defense
- MeSH terms
- Interferon alpha-2, Acute Disease, Animals, Blood, Body Temperature, Chlorocebus aethiops, Guinea Pigs, Humans, Marburg Virus Disease, Recombinant Proteins, Survival, Viremia, Interferon-alpha, Marburgvirus
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