Neuropsychological Aspects of Pediatric Sickle Cell Disease
Abstract
Sickle cell disease (SCD), a class of genetic disorders characterized by abnormal, sickled red blood cells, is a chronic illness that results in progressive cerebrovascular disease. Neurocognitive sequelae of clinically apparent cerebrovascular accidents in children with SCD are characterized by pervasive impairments, including decrements in general intellectual functioning, language and verbal abilities, visual-motor and visual-spatial processing, memory, academic achievement, and processing of subtle prosodic information. In contrast, subtle neurocognitive deficits in the areas of attention and concentration, executive function, and visual-motor speed and coordination appear to be associated with silent infarcts that are not necessarily detected on physical examination. Investigation of the disease course and associated neurocognitive sequelae suggest a disease-specific model of neuropsychological impairment. Recommendations are made for clinical and research efforts in the field of pediatric neuropsychology.
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The literature links memory deficits and diverse pediatric conditions.
“the abundant literature linking memory deficits and diverse pediatric conditions (e.g., traumatic brain injury, Woodward & Donders, 1998;Yeates, Blumenstein, Patterson, & Dellis, 1995; sickle cell disease, Kral, Brown, & Hynd, 2001;epilepsy, Cohen, 1992;Seidenberg et al., 1997;acute lymphoblastic leukemia, Waber & Mullenix, 2000).”
From Validation of a Developmental Neuropsychological Assessment (NEPSY) through comparison of neurological, scholastic concerns, and control groups (2004) · cites this paper as Kral, Brown, & Hynd, 2001
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Special Population: Children and Adolescents
McEachern, M. A., & Page, C. P. (2018) · Springer eBooks · doi:10.1007/978-3-319-71812-5_24
- Authors
- Kral, M. C., Brown, R. T., & Hynd, G. W.
- Affiliations
- Medical University of South Carolina (US)
- University of Georgia (US)
- Corresponding author
- Kral, Mary C.
- Venue
- Neuropsychology Review
- Published
- 2001-12
- Volume
- 11
- Issue
- 4
- Pages
- 179-196
- ISSN
- 1040-7308 (ISSN-L)
- 1573-6660
- OpenAlex
- W1502367468
- Cited by
- 86
- References
- 0
- Citations by year
- 2026: 1 · 2025: 6 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 5
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neuropsychology Review (publishedVersion)
- PubMed (publishedVersion)
- Digital Scholarship - UNLV (University of Nevada Reno) (submittedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Keywords
- sickle cell disease, pediatric sickle cell disease, neurocognitive impairment, cerebrovascular disease, silent cerebral infarction, intellectual functioning, memory, academic performance, prosodic processing, attention and concentration, executive function, visual motor speed, neuropsychological assessment
- MeSH terms
- Anemia, Sickle Cell, Brain, Brain Damage, Chronic, Cerebral Infarction, Child, Diagnostic Imaging, Humans, Neuropsychological Tests
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