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Cited by 213Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryGlioma Diagnosis and Treatment

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Chemotherapeutic Drugs Released from Polymers: Distribution of 1,3-bis(2-chloroethyl)-l-nitrosourea in the Rat Brain

Fung, Lawrence K., Shin, Marian, Tyler, Betty, Brem, Henry, Saltzman, W. Mark·1996·Pharmaceutical Research
DOI 10.1023/a:1016083113123
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Abstract

Purpose The distribution of [(3)H]BCNU following release from polymer implants in the rat brain was measured and evaluated by using mathematical models. Methods [(3)H]BCNU was loaded into p(CPP:SA) pellets, which were subsequently implanted intracerebrally in rats; [(3)H]BCNU was also directly injected into the brains of normal rats and rats with intracranially transplanted 9L gliomas. Concentrations of [(3)H]BCNU on coronal sections of the brain were measured by autoradiography and image processing. For comparison, the kinetics of [(3)H]BCNU release from the p(CPP:SA) polymer discs into phosphate-buffered saline were also measured. Results High concentrations of BCNU (corresponding to 1 mM) were measured near the polymer for the entire 30-day experiment. The penetration distance, defined as the distance from the polymer surface to the point where the concentration of [(3)H]BCNU in the tissue had dropped to 10 percent of the maximum value, was determined: penetration distance was 5 mm at day 1 and 1 mm at days 3 through 14. Local concentration profiles were compared with a mathematical model for estimation of the modulus phi (2), an indicator of the relative rate of elimination to diffusion in the brain. From day 3 to 14, phi(2) was 7, indicating that BCNU elimination was rapid compared to the rate of diffusive penetration into tissue. The enhanced penetration observed on day 1 appears to be due to convection of extracellular fluid caused by transient, vasogenic edema, which…

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Metadata

Authors
Fung, L. K., Shin, M., Tyler, B., Brem, H., & Saltzman, W. M.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Published
1996-05
Volume
13
Issue
5
Pages
671-682
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
DOI
10.1023/a:1016083113123
OpenAlex
W205461530
Cited by
213
References
34
Citations by year
2026: 6 · 2025: 5 · 2024: 7 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 12 · 2018: 13 · 2017: 10 · 2016: 15 · 2015: 12 · 2014: 11 · 2013: 10 · 2012: 12
FWCI
5.38
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1u01ca052857-01)
  • National Cancer Institute (U01-CA 52857)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Keywords
1,3-bis(2-chloroethyl)-1-nitrosourea, BCNU, brain drug distribution, polymer implants, controlled drug release, 9L glioma, intracerebral implantation, penetration depth, drug elimination kinetics, convection, vasogenic edema, mathematical modeling of drug release
MeSH terms
Animals, Autoradiography, Brain, Carmustine, Drug Carriers, Male, Microinjections, Polymers, Rats, Inbred F344, Tritium, Antineoplastic Agents, Alkylating, Rats

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