Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: effect of vanadate and fenugreek (Trigonella foenum graecum)
Abstract
With the premise that oxygen free radicals may be responsible for the severity and complications of diabetes, the level of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as the oxidative damage were examined in the tissues of control, diabetic and treated rats. After 3 weeks of diabetes, the activity of CAT was significantly increased in heart in diabetes (about 6-fold) but decreased in liver. The SOD activity decreased significantly in liver but increased in brain. The activity of GPx decreased significantly in liver and increased in kidney. A significant increase was observed in oxidative damage in heart and kidney and a small increase in brain with decrease in liver and muscle. Vanadate and fenugreek (Trigonella foenum graecum) administration to diabetic animals showed a reversal of the disturbed antioxidant levels and peroxidative damage. Results suggest that oxidative stress play a key role in the complications of diabetes. Vanadate and fenugreek seeds showed an encouraging antioxidant property and can be valuable candidates in the treatment of the reversal of the complications of diabetes.
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Peritoneal injection of Ecdy (16 mg/kg) for seven days resulted in significant decreases in neuronal death rate, brain water content, MDA content, and a noticeable increase in SOD enzymes in the hippocampus compared with the TBI group.
“The study with Shihao et al. on traumatic brain injury (TBI) in rats reported that peritoneal injection of Ecdy (16 mg/kg) for seven days resulted in signi cant decreases in the neuronal death rate, brain water content, MDA content, and a noticeable increase in SOD enzymes in the hippocampus compared with TBI group”
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References 40 · Cited by 258
- Authors
- Genet, S., Kale, R. K., & Baquer, N. Z.
- Affiliations
- Jawaharlal Nehru University (IN)
- Corresponding author
- Baquer, Najma Z.
- ORCID
- Genet, Solomon
- Venue
- Molecular and Cellular Biochemistry
- Published
- 2002-07
- Volume
- 236
- Issue
- 1-2
- Pages
- 7-12
- ISSN
- 0300-8177 (ISSN-L)
- 1573-4919
- OpenAlex
- W255295199
- Cited by
- 258
- References
- 40
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 12 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 18 · 2013: 25 · 2012: 16
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular and Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Inorganic Chemistry › Vanadium and Halogenation Chemistry
- Keywords
- diabetes mellitus, oxidative stress, antioxidant enzymes, catalase, superoxide dismutase, glutathione peroxidase, lipid peroxidation, vanadate, fenugreek, diabetes complications, tissue distribution of enzymes, heart, liver, kidney, brain
- MeSH terms
- Alloxan, Animals, Antioxidants, Body Weight, Brain, Catalase, Diabetes Mellitus, Experimental, Female, Glutathione Peroxidase, Insulin, Kidney, Liver, Organ Size, Plant Extracts, Superoxide Dismutase, Time Factors, Vanadates, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Trigonella, Rats
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