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About the origin of retroviruses and the co-evolution of the gypsy retrovirus with the Drosophila flamenco host gene
Abstract
The gypsy element of Drosophila melanogaster is the first retrovirus identified so far in invertebrates. According to phylogenetic data, gypsy belongs to the same group as the Ty3 class of LTR-retrotransposons, which suggests that retroviruses evolved from this kind of retroelements before the radiation of vertebrates. There are other invertebrate retroelements that are also likely to be endogenous retroviruses because they share with gypsy some structural and functional retroviral-like characteristics. Gypsy is controlled by a Drosophila gene called flamenco, the restrictive alleles of which maintain the retrovirus in a repressed state. In permissive strains, functional gypsy elements transpose at high frequency and produce infective particles. Defective gypsy proviruses located in pericentromeric heterochromatin of all strains seem to be very old components of the genome of Drosophila melanogaster, which indicates that gypsy invaded this species, or an ancestor, a long time ago. At that time, Drosophila melanogaster presumably contained permissive alleles of the flamenco gene. One can imagine that the species survived to the increase of genetic load caused by the retroviral invasion because restrictive alleles of flamenco were selected. The characterization of a retrovirus in Drosophila, one of the most advanced model organisms for molecular genetics, provides us with an exceptional clue to study how a species can resist a retroviral invasion.
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“Homozygous “permissive” loss of function alleles of flamenco allow transposable element mobilization and increase transposable element copy number within the Drosophila genome23,24.”
From Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies (2018) · cites this paper as [23]
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Metadata
- Authors
- Pélisson, A., Teysset, L., Chalvet, F., Kim, A., Prud'homme, N., Terzian, C., & Bucheton, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Genetica
- Published
- 1997-03
- Volume
- 100
- Issue
- 1-3
- Pages
- 29-37
- ISSN
- 0016-6707 (ISSN-L)
- 1573-6857
- OpenAlex
- W1540751634
- Cited by
- 65
- References
- 41
- Citations by year
- 2024: 2 · 2023: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Genetica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Diptera species taxonomy and behavior
- Keywords
- Drosophila melanogaster, endogenous retroviruses, LTR retrotransposons, Ty3 retrotransposon, retroviral restriction, pericentromeric heterochromatin, provirus, host-virus coevolution, genetic load
- MeSH terms
- Animals, Drosophila, Polymorphism, Genetic, Repetitive Sequences, Nucleic Acid, Retroviridae, Genome, Genes, Insect, Evolution, Molecular
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