An animal study on the bone behaviour of Ca–P-coated implants: influence of implant location
Abstract
Four different implant materials were installed into the mandibular corner of goats to investigate the trabecular bone response in a mainly unloaded model. The implants were installed using a standardized technique and were left in situ for 12 weeks. One goat had to be sacrificed after surgery because of a broken rib; the other animals healed uneventfully. After sacrifice of the animals, the bone response to the uncoated and the three different Ca-P implants was evaluated histologically and histomorphometrically. Four sections of each implant were evaluated; two were located in the cortical and two in the trabecular bone. Of the 44 retrieved implants, 20 implants appeared to be installed partially in the mandibular canal, as clearly visible on the X-rays. These implants were not used in the histomorphometrical measurements. Histological evaluation showed that the trabecular and cortical bone reactions were similar; there was no significant difference in the percentage of bone contact nor in the amount of bone in contact with the implants. In conclusion this study showed that the mandibular corner is an unsatisfactory model for the installation of implants because of anatomical restrictions. Also, the experiment remained inconclusive about the influence of loading conditions on bone behaviour. Nevertheless, the histological results confirmed the bioactive properties of Ca-P coatings.
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Thermal annealing of PDA at 150 °C under an inert atmosphere for 2 h induces partial graphitization and prolongs the degradation half-life.
“Alternatively, thermal annealing of PDA at 150 °C under an inert atmosphere for 2 h has been employed to induce partial graphitization.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [109]
These stabilization strategies were shown to prolong the degradation half-life from approximately 45 days to 90 days and 160 days, respectively.
“These strategies were shown to prolong the degradation half-life from approximately 45 days to 90 days and 160 days, respectively.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [109]
The introduction of 0.5% (3-aminopropyl)triethoxysilane during self-polymerization forms organic-inorganic hybrid layers that prolong the degradation half-life of PDA.
“One approach involves the introduction of 0.5% (3-aminopropyl)triethoxysilane during the self-polymerization process to form organic–inorganic hybrid layers.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [109]
High-temperature treatment inevitably reduces the density of surface-active functional groups.
“However, high-temperature treatment inevitably reduces the density of surface-active functional groups, highlighting the need to balance long-term stability against the preservation of functionalization capacity.5,109”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [109]
Cited by
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Yang, Z., Song, W., Lv, L., Zhai, S., Liu, Y., Cui, H., Li, X., Gao, F., & Chu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s611922
“5,109”
- Authors
- CAULIER, H., HAYAKAWA, T., NAERT, I., VAN DER WAERDEN, J. P. C. M., WOLKE, J. G. C., & JANSEN, J. A.
- Affiliations
- Radboud University Nijmegen (NL)
- Nihon University (JP)
- KU Leuven (BE)
- Venue
- Journal of Materials Science: Materials in Medicine
- Published
- 1997-09
- Volume
- 8
- Issue
- 9
- Pages
- 531-536
- ISSN
- 0957-4530 (ISSN-L)
- 1573-4838
- OpenAlex
- W1742450986
- Cited by
- 11
- References
- 0
- Citations by year
- 2023: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Materials Science Materials in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Keywords
- calcium phosphate coatings, bioactive implants, implantation site, mandibular canal, bone-implant contact, bone regeneration, goat model, unloading, histomorphometry
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