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Cited by 38Orthopaedic implants and arthroplastyOrthopedic Infections and TreatmentsBone Metabolism and Diseases

The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.

Modulation of the phenotypic and functional properties of phagocytic macrophages by wear particles from orthopaedic implants

AL-SAFFAR, N, REVELL, P. A, KOBAYASHI, A·1997·Journal of Materials Science: Materials in Medicine
DOI 10.1023/a:1018575504518
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Abstract

An attempt was made to assess the local chronic inflammatory response in patients with failed orthopaedic implant that is clinically associated with osteolysis, bone and bone marrow necrosis. The main objective was to analyse the heterogeneity of the macrophage functional subsets in the bone-implant interface membrane and to evaluate their possible role in the development of an erosive inflammatory lesion within the bone. Immunohistology was performed on 21 specimens of the bone-implant interface obtained from 17 patients during revision arthroplasty, and synovial membranes from rheumatoid (RA, n=4), and osteoarthritis (OA, n=4) patients. Three well-characterized monoclonal antibodies (MAb) recognizing antigenic determinants on specific functional subsets of macrophages (Mphi) were used. RFD1 (interdigitating reticulum cells/antigen presenting cells, (APC), RFD7 (mature phagocytic macrophages), and RFD9 epithelioid cells and foreign body giant cells (FBGC). RFD1 was expressed on a variable number of perivascular and synovial lining Mphi in both RA and OA synovia, at a frequency of 25%-40%. In cases with total joint replacements, the interface showed a marked increase in the expression of RFD1 (20%-90%). A considerably greater percentage of RFD1 positive Mphi and FBGC was noted in the interfaces from cases with a high level of detectable metal particulate wear debris (mean 80%, range 60%-90%) than in cases with polyethylene wear debris (mean 30%, range 0%-50%), p 0.0001. RFD7…

Overview

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Crossref · 10.1023/a:1018575504518

Cites

39 of 39 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 40 references

Research works printed but not linked: 7

  1. G JANOSSY, M. BOFILL, L. W. POULTER, in “Immunocytochemistry today” (Wright, Bristol, 1985).
  2. C. S. MUNRO, D. A. CAMPBELL, L. A. COLLINGS and L. W. POULTER, Clin. Exp. Immunol. 68 (1987) 282.
  3. A. C. H. M. VAN DINTHER-JANSSEN, S.T. PALS, R. SCHEPER, F. BREEDVALD and C.J.L.M. MEIJER, J. Rheumatol. 17 (1990) 11.
  4. V. A. ALEGRE, D. M. MacDONALD, L. W. POULTER Clin. Exp. Immunol. 64 (1986) 330.
  5. M. A. SPITERI, S. W. CLARKE and L. W. POULTER, ibid. 74 (1988) 359.
  6. L. A. COLLING, M. F. R. WATERS and L. W. POULTER, ibid. 62 (1985) 458.
  7. N. HOGG, S. MacDONALD, M. SLUSARANKO and P. C. L. BEVERLEY, Immunology 53 (1984) 753.

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Metadata

Authors
AL-SAFFAR, N., REVELL, P. A., & KOBAYASHI, A.
Affiliations
The Royal Free Hospital (GB)
ORCID
KOBAYASHI, A
Venue
Journal of Materials Science: Materials in Medicine
Publisher
Springer Science and Business Media LLC
Published
1997-11
Volume
8
Issue
11
Pages
641-648
ISSN
  • 0957-4530 (ISSN-L)
  • 1573-4838
DOI
10.1023/a:1018575504518
OpenAlex
W348347653
Cited by
38
References
40
Citations by year
2025: 1 · 2021: 2 · 2020: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 1
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Materials Science Materials in Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
  • Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
macrophage heterogeneity, metal wear debris, bone-implant interface, chronic inflammation, osteolysis, foreign body giant cells, antigen-presenting macrophages, synovial macrophages, rheumatoid arthritis, osteoarthritis, total joint arthroplasty, revision arthroplasty, polyethylene wear debris

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.