The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.
The Cold Origin of Life: B. Implications Based on Pyrimidines and Purines Produced From Frozen Ammonium Cyanide Solutions
Abstract
A wide variety of pyrimidines and purines were identified as products of a dilute frozen ammonium cyanide solution that had been held at -78 degrees C for 27 years. This demonstrates that both pyrimidines and purines could have been produced on the primitive earth in a short time by eutectic concentration of HCN, even though the concentration of HCN in the primitive ocean may have been low. We suggest that eutectic freezing is the most plausible demonstrated mechanism by which HCN polymerizations could have produced biologically important prebiotic compounds.
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“Second, the rate at which different monomers are polymerized can vary by an order of magnitude (6,17–20).”
From Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences (2012) · cites this paper as [6]
In the citing paper
“For example, a concentrated eutectic phase solution of ammonium cyanide yields significantly more adenine than guanine, uracil and cytosine (roughly 10× or more) (6).”
From Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences (2012) · cites this paper as [6]
Citations
Cites
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Activated Acetic Acid by Carbon Fixation on (Fe,Ni)S Under Primordial Conditions
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Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet
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Infrared Observations of the Saturnian System from Voyager 1
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Synthesis of adenine from ammonium cyanide
Oro, J. A. (1960) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(60)90138-8 · Cited by 482
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Primordial Carbonylated Iron-Sulfur Compounds and the Synthesis of Pyruvate
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Research works printed but not linked: 1
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Prebiotic chemistry and the origin of the RNA world.
Leslie E., O. (2004) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230490460765 · Cited by 1,124
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Carbonaceous Meteorites Contain a Wide Range of Extraterrestrial Nucleobases
Callahan, M. P., Smith, K. E., Cleaves, H. J., Ruzicka, J., Stern, J. C., Glavin, D. P., House, C. H., & Dworkin, J. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106493108 · Cited by 590
Self-citationOrigins of building blocks of life: A review
Kitadai, N., & Maruyama, S. (2018) · Geoscience Frontiers · doi:10.1016/j.gsf.2017.07.007 · Cited by 464
Extraterrestrial nucleobases in the Murchison meteorite
Martins, Z., Botta, O., Fogel, M. L., Sephton, M. A., GLAVIN, D. P., Watson, J. S., Dworkin, J. P., Schwartz, A. W., & Ehrenfreund, P. (2008) · Earth and Planetary Science Letters · doi:10.1016/j.epsl.2008.03.026 · Cited by 418
Metadata
- Authors
- Miyakawa, S., Cleaves, H. J., & Miller, S. L.
- Affiliations
- Yokohama National University (JP)
- University of California San Diego (US)
- ORCID
- Cleaves, H. James
- Venue
- Origins of life and evolution of the biosphere
- Published
- 2002-06
- Volume
- 32
- Issue
- 3
- Pages
- 209-218
- ISSN
- 0169-6149 (ISSN-L)
- 1573-0875
- OpenAlex
- W1570440484
- Cited by
- 174
- References
- 60
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 3 · 2019: 1 · 2018: 9 · 2017: 7 · 2016: 3 · 2015: 8 · 2014: 6 · 2013: 14 · 2012: 15
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Origins of Life and Evolution of Biospheres (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Space Science and Extraterrestrial Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- origin of life, pyrimidines, purines, ammonium cyanide, frozen solutions, prebiotic chemistry, early Earth, nucleobase synthesis
- MeSH terms
- Origin of Life, Cold Temperature, Cyanides, Purines, Pyrimidines, Solutions
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