The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Intracerebral Production of Tumor Necrosis Factor-α, a Local Neuroprotective Agent, in Alzheimer Disease and Vascular Dementia
Abstract
The local pattern of proinflammatory cytokine release was studied in Alzheimer disease (AD) and vascular dementia (VAD), by measuring intrathecal levels of IL-1 beta, IL-6, TNF-alpha, and its naturally occurring antagonists, soluble TNF receptors I and II. The cytokine levels were related to neuronal damage, as measured by the intrathecal tau concentration, to cerebral apoptosis assessed by levels of Fas/APO-1 and bcl-2, and to clinical variables. In vitro analysis was performed to study the effect of TNF-alpha on the production of bcl-2, an antiapoptotic factor, by human neuronal cells. Patients with both AD and VAD displayed significantly higher intrathecal levels of TNF-alpha compared to controls. In addition, patients with AD showed significantly negative correlations between the intrathecal levels of TNF-alpha and the levels of Fas/APO-1 as well as of tau protein. The level of bcl-2 in supernatants of TNF-alpha-exposed cultures of human neuronal cells was up to three times higher than in control supernatants. Our study demonstrates intrathecal production of TNF-alpha in patients with dementias, suggesting that this cytokine may have a neuroprotective role in these neurodegenerative conditions as evidenced by negative correlations between this cytokine and (i) levels of intrathecal Fas/APO-1 and (ii) levels of tau protein, both parameters closely related to brain damage. Our in vitro data suggest that TNF-alpha exerts its neuroprotective effect by stimulating neuronal cells to express bcl-2, a molecule which downregulates apoptosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“TNF-α levels were also found to be elevated in the CSF of AD patients and correlate with disease progression [145, 146].”
From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [145]
Citations
Cites
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,188
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777
Activation of microglial cells by β-amyloid protein and interferon-γ
Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314
Biedler, J. L., Helson, L., & Spengler, B. A. (1973) · PubMed · Cited by 1,295
Production of hybridoma growth factor by human monocytes
Aarden, L. A., de Groot, E. R., Schaap, O. L., & Lansdorp, P. M. (1987) · European Journal of Immunology · doi:10.1002/eji.1830171004 · Cited by 1,091
Martinou, J., Dubois‐Dauphin, M., Staple, J. K., Rodríguez, I., Frankowski, H., Missotten, M., Albertini, P., Talabot, D., Catsicas, S., & Pietra, C. (1994) · Neuron · doi:10.1016/0896-6273(94)90266-6 · Cited by 1,087
Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.
Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., & Cotman, C. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7951 · Cited by 1,029
Mandelkow, E. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01368-3 · Cited by 980
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
Itoh, N., & Nagata, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82075-0 · Cited by 845
Research works printed but not linked: 4
- Iqbal K: Prevalence and neurobiology of Alzheimer disease: Some highlights. In Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies, K Iqbal, DRC McLachlan, B Winblad, HM Wisniewski (eds). Chichester, Wiley-Interscience, 1991, pp 9-12
- Rossor M: Disorders of psychic function. Dementia. In Disease of the Nervous System: Clinical Neurobiology, 2nd ed, AK Asbury, GM McKhann, WI McDonald (eds). Philadelphia, W. B. Saunders, 1992, pp 788-794
- St. Pierre BA, Merill JE, Dopp JM: Effects of cytokines on the CNS cells: Glia. In Cytokines and the CNS, RM Ransohoff, EN Benveniste (eds). Boca Raton, FL, CRC Press, 1996, pp 151-168
- Wallin A, Blennow K, Scheltens PH: Research criteria for clinical diagnosis of “pure” Alzheimers disease. Drugs Today 30:265-273, 1994
Cited by
Sorted by citations
Items 201–300 of 348
Tobinick, E. L. (2012) · Current Alzheimer Research · doi:10.2174/156720512799015073 · Cited by 34
Biomarkers for Alzheimer Disease in Cerebrospinal Fluid, Urine, and Blood
Lönneborg, A. (2008) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256296 · Cited by 33
Lee, M. H., Park, D., Back, D.-B., Lee, J.-Y., Lee, C.-I., Park, K.-J., Kang, S.-H., Cho, T.-H., & Chung, Y.-G. (2012) · Medical Science Monitor · doi:10.12659/msm.883586 · Cited by 30
Pentraxins and Alzheimer's disease: At the interface between biomarkers and pharmacological targets
Osera, C., Pascale, A., Amadio, M., Venturini, L., Govoni, S. M., & Ricevuti, G. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.004 · Cited by 30
Blood-Based Protein Biomarkers for Diagnosis and Classification of Neurodegenerative Diseases
Noelker, C., Hampel, H. J., & Dodel, R. C. (2011) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256398 · Cited by 29
Variants of Base Excision Repair Genes MUTYH, PARP1 and XRCC1 in Alzheimer's Disease Risk
Kwiatkowski, D., Czarny, P. L., Gałecki, P., Bachurska, A., Talarowska, M. E., Orzechowska, A., Bobińska, K., Bielecka-Kowalska, A., Pietras, T., Szemraj, J., et al. (2015) · Neuropsychobiology · doi:10.1159/000381985 · Cited by 29
Safieh‐Garabedian, B., Ochoa‐Chaar, C. I., Poole, S., Massaad, C. A., Atweh, S., Jabbur, S. J., & Saadé, N. E. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00500-1 · Cited by 29
Inflammatory Mediators in the Frontal Lobe of Patients with Mixed and Vascular Dementia
Mulugeta, E., Molina‐Holgado, F., Elliott, M. S. J., Hortobágyi, T., Perry, R., Kalaria, R. N., Ballard, C. G., & Francis, P. T. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000118633 · Cited by 29
Intereleukin-10 Promoter Polymorphism in Mild Cognitive Impairment and in Its Clinical Evolution
Arosio, B., Mastronardi, L., Vergani, C., & Annoni, G. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/854527 · Cited by 29
Associations Between Serum Inflammatory Markers and Hippocampal Volume in a Community Sample
Schmidt, M. F., Freeman, K. B., Windham, B. G., Griswold, M. E., Kullo, I. J., Turner, S. T., & Mosley, T. H. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14283 · Cited by 28
Cardiovascular Dementia - A Different Perspective
Kumari, U., & Heese, K. (2010) · The Open Biochemistry Journal · doi:10.2174/1874091x01004010029 · Cited by 27
Lee, C., Low, C. Y. B., Wong, S. Y., Lai, M. K. P., & Tan, M. G. K. (2017) · Scientific Reports · doi:10.1038/srep43651 · Cited by 27
Hydroxychavicol inhibits immune responses to mitigate cognitive dysfunction in rats
Pandey, A., & Bani, S. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.05.031 · Cited by 27
Calsavara, A. J. C., Soriani, F. M., Vieira, L. Q., Costa, P. A., Rachid, M. A., & Teixiera, A. L. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9610-8 · Cited by 26
Anuradha, U., Kumar, A., & Singh, R. K. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05343-7 · Cited by 24
Diabetic encephalopathy: the role of oxidative stress and inflammation in type 2 diabetes
Reis, F., Soares, Nunes, & Pereira, F. C. (2012) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s29322 · Cited by 26
Heat Shock Protein 70 and Tumor Necrosis Factor Alpha in Taiwanese Patients with Dementia
Fung, H., Chen, C. M., Wu, Y.-Y., Hsu, W.-W., Ro, L. ‐., Lin, J., Chang, K. H., Wang, H., Lin, S., Chan, H.-L., et al. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000085067 · Cited by 24
Insight into the Molecular Imaging of Alzheimer’s Disease
Arora, A., & Bhagat, N. (2016) · International Journal of Biomedical Imaging · doi:10.1155/2016/7462014 · Cited by 23
Intrathecal Release of Nitric Oxide in Alzheimer’s Disease and Vascular Dementia
Tarkowski, E., Ringqvist, Å., Blennow, K., Wallin, A., & Wennmalm, Å. (2000) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017261 · Cited by 23
Self-citationCharacterisation of amyloid-induced inflammatory responses in the rat retina
Howlett, D. R., Bate, S. T., Collier, S., Lawman, A. J., Chapman, T. D., Ashmeade, T. E., Marshall, I. C. B., Anderson, P. J., Philpott, K. L., Richardson, J. C., et al. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2819-4 · Cited by 22
Li, H., Huynh, T. N. T., Duong, M. T., Gow, J. G., Chang, C. C. Y., & Chang, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065616 · Cited by 19
The "Alzheimer's disease signature": potential perspectives for novel biomarkers
Davinelli, S., Intrieri, M., Russo, C., Costanzo, A. D., Zella, D., Bosco, P., & Scapagnini, G. (2011) · Immunity & Ageing · doi:10.1186/1742-4933-8-7 · Cited by 22
Puga, A. M., Ruperto, M., Samaniego-Vaesken, M. D. L., Montero-Bravo, A., Partearroyo, T., & Varela‐Moreiras, G. (2021) · Nutrients · doi:10.3390/nu13092966 · Cited by 23
Immunological Aspects of Alzheimer??s Disease
Hoozemans, J. J. M., Rozemüller, A. J. M., Veerhuis, R., & Eikelenboom, P. (2001) · BioDrugs · doi:10.2165/00063030-200115050-00004 · Cited by 21
Pulliam, L., Irwin, I., Kusdra, L., Rempel, H. C., Flitter, W. D., & Garland, W. A. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03293-5 · Cited by 21
Calsavara, A. J. C., Soriani, F. M., Vieira, L. Q., Costa, P. A., Rachid, M. A., & Teixeira, A. L. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9620-6 · Cited by 21
Molecular Regulation Mechanism of Microglial Autophagy in the Pathology of Alzheimer's Disease
Ou-Yang, P., Cai, Z., & Zhang, Z.-H. (2023) · Aging and Disease · doi:10.14336/ad.2023.0106 · Cited by 21
Alzheimer’s Disease Patients Display Gender Dimorphism in Circulating Anorectic Adipokines
Intebi, A. D., Garau, L., Brusco, I., Pagano, M. A., Gaillard, R. C., & Spinedi, E. (2002) · NeuroImmunoModulation · doi:10.1159/000071476 · Cited by 20
Arosio, B., Mastronardi, L., Gussago, C., Nicolini, P., Casè, A., Ziglioli, E., & Bergamaschini, L. C. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/484021 · Cited by 20
Soysal, P., Tan, S. G., Rogowska, M., Jawad, S., Smith, L., Veronese, N., Tsiptsios, D., Tsamakis, K., Stewart, R. J., & Mueller, C. (2021) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5659 · Cited by 18
Salai, K. H. T., Wu, L., Chong, J. R., Chai, Y. L., Gyanwali, B., Robert, C., Hilal, S., Venketasubramanian, N., Dawe, G. S., Chen, C., et al. (2023) · Biomolecules · doi:10.3390/biom13030525 · Cited by 20
Finding a pathological diagnosis for A lzheimer's disease: Are inflammatory molecules the answer?
Bhamra, M. S., & Ashton, N. J. (2012) · Electrophoresis · doi:10.1002/elps.201200161 · Cited by 21
Luo, W., Tweedie, D., Beedie, S., Vargesson, N., Figg, W. D., Greig, N. H., & Scerba, M. T. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.01.032 · Cited by 18
Clapcote, S. J. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-58811-7_5 · Cited by 18
Heparan sulfate proteoglycan induces the production of NO and TNF-α by murine microglia
Bussini, S., Meda, L., Scarpini, E. A., Clementi, E., Conti, G. M., Tiriticco, M., Bresolin, N., & Baron, P. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-11 · Cited by 17
Biomarkers of Alzheimer disease in plasma
Irizarry, M. C. (2004) · Neurotherapeutics · doi:10.1007/bf03206606 · Cited by 17
Jagadeesan, N., Roules, G. C., Chandrashekar, D. V., Yang, J., Kolluru, S., & Sumbria, R. K. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05008-x · Cited by 19
Psychotropic Drug Effects on Gene Transcriptomics Relevant to Alzheimer Disease
Lauterbach, E. C. (2011) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318214b7d0 · Cited by 15
Saeidikhoo, S., Ezi, S., Khatmi, A., Aghajanpour, F., Soltani, R., Abdollahifar, M., Jahanian, A., & Aliaghaei, A. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01522-x · Cited by 16
Serum BDNF, TNF- α and IL-1β levels in dementia patients
Yasutake, C. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-0702-2 · Cited by 16
Zhang, X., Wang, D., Liu, Y., Sun, J., Fan, B., Wang, F., & Lü, C. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120219 · Cited by 15
Circulating inflammatory cytokine levels correlates with cognitive impairment
Marzabadi, L. R., Sadigh‐Eteghad, S., & Talebi, M. (2020) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12613 · Cited by 15
Gao, Q., Camous, X., Lu, Y., Lim, M.-L., Larbi, A., & Ng, T. P. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.12.002 · Cited by 15
Guest, J., Grant, R., Garg, M. L., Mori, T. A., Croft, K. D., & BILGIN, A. A. B. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-117 · Cited by 15
Neuronal c-Abl activation leads to induction of cell cycle and interferon signaling pathways
Schlatterer, S. D., Suh, H.-S., Conejero‐Goldberg, C., Chen, S., Acker, C. M., Lee, S. C., & Davies, P. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-208 · Cited by 15
Kern, S., Skoog, I., Börjesson-Hanson, A., Blennow, K., Zetterberg, H., Östling, S., Kern, J., Gudmundsson, P., Marlow, T., Rosengren, L., et al. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.03.011 · Cited by 13
Self-citationRetractedGao, H., Findeis, E. L., Culmone, L., Powell, B., Landschoot‐Ward, J., Zacharek, A., Wu, T., Lü, M., Chopp, M., & Venkat, P. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1180913 · Cited by 13
Edwards, M., Balldin, V. H., Hall, J. R., & O’Bryant, S. E. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140852 · Cited by 14
CanToxoplasma gondiiPave the Road for Dementia?
Saftawy, E. A. E., Amin, N. M. A., Sabry, R. M., El‐Anwar, N., Shash, R. Y., Elsebaie, E. H., & Wassef, R. M. (2020) · Journal of Parasitology Research · doi:10.1155/2020/8859857 · Cited by 13
Huang, H., Chang, J. C., Liu, H.-C., Yang, Z.-Y., Yang, Y.-J., Chen, L., & Yen, D. H.-T. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111138 · Cited by 12
Recent advances in pre-clinical diagnosis of Alzheimer’s disease
Zhou, J., Benoit, M., & Sharoar, M. G. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00733-4 · Cited by 14
Lucarelli, P., Piciullo, A., Verdecchia, M., Palmarino, M., Arpino, C., & Curatolo, P. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.08.021 · Cited by 11
Braghin, E., Galimberti, D., Scarpini, E. A., Bresolin, N., & Baron, P. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.09.057 · Cited by 11
Atherosclerosis, biomarkers of atherosclerosis and Alzheimer's disease
Fiolaki, A., Tsamis, K. I., Milionis, H. J., Kyritsis, A. P., Kosmidou, M. S., & Giannopoulos, S. (2013) · International Journal of Neuroscience · doi:10.3109/00207454.2013.821988 · Cited by 11
Poetsch, V., Neuhaus, W., & Noe, C. R. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-090769 · Cited by 11
Hernandez, C. M., McCuiston, M. A., Davis, K., Halls, Y., Zotto, J. P. C. D., Jackson, N. L., Dobrunz, L. E., King, P. H., & McMahon, L. L. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100798 · Cited by 11
Sasayama, D., Hattori, K., Yokota, Y., Matsumura, R., Teraishi, T., Yoshida, S., & Kunugi, H. (2020) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12110 · Cited by 9
Chiappelli, M., Tumini, E., Porcellini, E., & Licastro, F. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.9.1327 · Cited by 10
Brain Atrophy, Anti-Smooth Muscle Antibody and Cognitive Impairment: An Association Study
Paroni, G., Lauriola, M., Andrea, F., D’Onofrio, G., Ciccone, F., Paris, F., Cascavilla, L., Urbano, M., Gravina, C., Copetti, M., et al. (2016) · Aging and Disease · doi:10.14336/ad.2015.1124 · Cited by 9
Hong, X., Chen, T., Liu, Y., Li, J., Huang, D., Ye, K., Liao, W., Wang, Y., Liu, M., & Luan, P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102669 · Cited by 9
Astrocytes and Inflammatory Processes in Alzheimer’s Disease
Vallés, S. L., Burguet, F., Iradi, A., Aldasoro, M., Vila, J. M., Aldasoro, C., & Jorda, A. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.88701 · Cited by 9
The Common Alzheimer's Disease Research Ontology (CADRO) for biomarker categorization
Osse, A. M. L., Kinney, J. W., & Cummings, J. L. (2025) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70050 · Cited by 7
Ren, W., Yan, X.-S., Fan, J.-C., Huo, D.-S., Wang, X., Jia, J., & Yang, Z.-J. (2024) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2024.2336570 · Cited by 7
Subventricular zone neural progenitors reverse TNF-alpha effects in cortical neurons
Morini, R., Ghirardini, E., Butti, E., Verderio, C., Martino, G., & Matteoli, M. (2015) · Stem cell research & therapeutics · doi:10.1186/s13287-015-0158-2 · Cited by 6
Pearce, J. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.020321 · Cited by 7
Bazyar, Y., Rafiei, S., Hosseini, A., & Edalatmanesh, M. A. (2015) · The Neuroscience Journal of Shefaye Khatam · doi:10.18869/acadpub.shefa.3.3.21 · Cited by 7
The influence of tumour necrosis factor- α (TNF-α) on amyloid-β (Aβ)-degrading enzymes in vitro.
Culpan, D., Palmer, J. C., Miners, J. S., Love, S., & Kehoe, P. G. (2011) · PubMed Central · Cited by 7
Amyloid Beta, TNFα and FAIM-L; Approaching New Therapeutic Strategies for AD
Carriba, P., & Comella, J. X. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00276 · Cited by 7
What Have We Learned from the Tau Hypothesis?
Maccioni, R. B., Farias, G. A., Rojo, L. E., Sekler, M. A., & Kuljiš, R. O. (2009) · Springer eBooks · doi:10.1007/978-0-387-87995-6_5 · Cited by 7
Lewis, T. J., & Trempe, C. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812112-2.00007-0 · Cited by 8
Neuroinflammation in Alzheimer's, Parkinson's and Huntington's Diseases
Sastre, M., Katsouri, L., Birch, A. M., Renziehausen, A., Dexter, D. T., Crichton, R. R., & Ward, R. J. (2014) · Wiley eBooks · doi:10.1002/9781118406557.ch6 · Cited by 6
Garcia‐Argibay, M., Hiyoshi, A., & Montgomery, S. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-074110 · Cited by 5
Modeling Sympathetic Hyperactivity in Alzheimer’s Related Bone Loss
Culibrk, R. A., Arabiyat, A. S., DeKalb, C. A., & Hahn, M. S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215007 · Cited by 5
Processo Inflamatório e Neuroimunomodulação na Doença de Alzheimer
Rocha, N. P., Martins, L. D. C. A., Teixeira, A. L., & Reis, H. J. (2001) · Revista Neurociências · doi:10.34024/rnc.2011.v19.8385 · Cited by 24
Kielian, T., & Drew, P. D. (2005) · Humana Press eBooks · doi:10.1385/1-59259-905-2:041 · Cited by 4
Immunodepressed Status of Mice after Bulbectomy
Novoselova, E. G., Бобкова, Н. В., Glushkova, O. V., Sinotova, O. A., Ogay, V. B., Medvinskaya, N. I., & Samokhin, A. N. (2004) · Biology Bulletin · doi:10.1023/b:bibu.0000049734.07925.d8 · Cited by 4
Reasonable neuropsychological battery to identify mild cognitive impairment
Zhao, S., Liu, G., Shen, Y., & Zhao, Y. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.08.028 · Cited by 3
Early Diagnosis of Alzheimer's Disease with Blood Test; Tempting but Challenging.
Farvadi, F., Hashemi, F., Amini, A., Vakilinezhad, M. A., & Raee, M. J. (2023) · PubMed Central · doi:10.22088/ijmcm.bums.12.2.172 · Cited by 3
Huang, Y., Erdmann, N. B., Hexum, T. D., & Zheng, J. (2008) · Springer eBooks · doi:10.1007/978-0-387-72573-4_15 · Cited by 3
The Immune State of Bulbectomized Mice
Novoselova, E. G., Бобкова, Н. В., Sinotova, O. A., Ogay, V. B., Glushkova, O. V., Medvinskaya, N. I., & Samokhin, A. N. (2003) · Doklady Biological Sciences · doi:10.1023/b:dobs.0000010308.59629.c0 · Cited by 3
Jefferson, A. L., Gentile, A. M., & Kahlon, R. S. (2011) · Wiley eBooks · doi:10.1002/9781444344110.ch2 · Cited by 3
TNF-α induces type I IFN signalling to suppress neurogenesis and recruit T cells
Nissen, T. A. D., Baig, A., Farmand, S., Rock, D. T., Shibu, S., Lee, H., O'Neill, L. A., Houghton, V., John, S., Klavinskis, L. S., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74104-x · Cited by 2
Efficacy and Safety of Stem Cell Therapy in Alzheimer's Disease: A Review
Arora, D., Gupta, D., Deeksha, Taneja, Y., & Dhingra, A. K. (2024) · Current Stem Cell Research & Therapy · doi:10.2174/011574888x267673231120061600 · Cited by 2
Hoyer, S., & Frölich, L. (2007) · Springer eBooks · doi:10.1007/978-0-387-30377-2_12 · Cited by 2
Cerebrospinal fluid biomarkers for neurodegenerative disorders
Videira, R. M. A. S. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 2
Cellular and molecular mechanisms of Alzheimer’s disease inflammation
Peery, H. E., Strohmeyer, R., & Rogers, J. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8350-4_1 · Cited by 2
Rezaei, E., & Biology, P. C. I. A. (2020) · SRPH Journal of Fundamental Sciences and Technology · doi:10.29252/sjfst.2.1.1 · Cited by 2
Decline of Immune Responsiveness: A Pathogenetic Factor in Alzheimer’s Disease?
Richartz-Salzburger, E., & Koehler, N. K. U. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_61 · Cited by 2
Ling, Y., Sun, J., Hu, L., Zhao, M., Chen, J., & Zheng, Y. (2025) · Brain and Behavior · doi:10.1002/brb3.71341 · Cited by 1
Microbiota–Gut–Brain Axis: An Integrative Overview of Communication Pathways
Martínez‐Porchas, M., Medina‐Félix, D., Olivas-Bernal, C. A., Guirado-Flores, J. S. O., Vargas‐Albores, F., Porchas‐Quijada, M., & Garibay-Valdéz, E. (2026) · Advanced Gut & Microbiome Research · doi:10.1155/agm3/8142006 · Cited by 1
The Role of Insulin Resistance in Age-Related Cognitive Decline and Dementia
Watson, G. S., & Craft, S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-850-8_18 · Cited by 1
Biomarkers in vascular dementia
Wallin, A., & Pirttilä, T. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511575976.008 · Cited by 1
Self-citationNovel Somatostatin Receptor Subtype‐4 Agonist Mitigates Microglia Inflammatory Activation
Silwal, A., Mobayen, S., Crider, A. M., Neumann, W. L., House, A., Umbaugh, D. S., Bhandari, S., Sandoval, K. E., & WITT, K. A. (2019) · The FASEB Journal · doi:10.1096/fasebj.2019.33.1_supplement.501.3 · Cited by 1
Ikezu, T. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_30 · Cited by 1
Huang, Y., & Zheng, J. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_17 · Cited by 1
Rojo, L. E., Fernández, J. A., Jiménez, J. M., Maccioni, A. A., Sekler, A., Kuljiš, R. O., & Maccioni, R. B. (2009) · Springer eBooks · doi:10.1007/978-0-387-87995-6_11 · Cited by 1
Omega-3 fatty acid treatment in mild to moderate Alzheimer's disease : Results from the OmegAD study
Freund‐Levi, Y. (2008) · Figshare · Cited by 1
Bronge, L. H., Wahlund, L., Brauner, A., Basun, H., & Garlind, A. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00025-6 · Cited by 1
Alzheimer’s disease: from pathogenesis to novel therapeutic approaches
Scarpini, E. A., & Galimberti, D. (2009) · Therapy · doi:10.2217/14750708.6.2.259 · Cited by 1
Blood-Brain Barrier Permeability and Inflammation in Cerebral Small Vessel Disease
Walsh, J. (2019) · Apollo (University of Cambridge) · doi:10.17863/cam.50869 · Cited by 2
Metadata
- Authors
- Tarkowski, E., Blennow, K., Wallin, A., & Tarkowski, A.
- Affiliations
- University of Gothenburg (SE)
- Varberg Hospital (SE)
- ORCID
- Blennow, Kaj
- Venue
- Journal of Clinical Immunology
- Published
- 1999-07
- Volume
- 19
- Issue
- 4
- Pages
- 223-230
- ISSN
- 0271-9142 (ISSN-L)
- 1573-2592
- OpenAlex
- W231832547
- Cited by
- 349
- References
- 42
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 18 · 2023: 11 · 2022: 2 · 2021: 8 · 2020: 15 · 2019: 5 · 2018: 7 · 2017: 12 · 2016: 12 · 2015: 13 · 2014: 24 · 2013: 7 · 2012: 18
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- TNF-α, Alzheimer's disease, vascular dementia, neuroinflammation, neuroprotection, apoptosis, Fas/APO-1, Bcl-2, tau protein, soluble TNF receptors, inflammatory cytokines, neuronal injury
- MeSH terms
- Aged, Alzheimer Disease, Brain, Female, Humans, Interleukin-1, Male, Middle Aged, Neurons, Tumor Necrosis Factor-alpha, Dementia, Vascular, Interleukin-6, tau Proteins, Apoptosis, Receptors, Tumor Necrosis Factor, Neuroprotective Agents, fas Receptor, Proto-Oncogene Proteins c-bcl-2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review