The DOI matches its Crossref record; 16 of the 18 references it cites were found in a registry or an index.
Plasma Amino Acid Levels in Children with Autism and Their Families
Abstract
Plasma amino acid levels were measured in autistic and Asperger syndrome patients, their siblings, and parents. The results were compared with values from age-matched controls. Patients with autism or Asperger syndrome and their siblings and parents all had raised glutamic acid, phenylalanine, asparagine, tyrosine, alanine, and lysine (p < .05) than controls, with reduced plasma glutamine. Other amino acids were at normal levels. These results show that children with autistic spectrum disorders come from a family background of dysregulated amino acid metabolism and provide further evidence for an underlying biochemical basis for the condition.
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“amino-acid transport and degradation differ between TD and ASD individuals (Aldred et al., 2003; Evans et al., 2008)”
From Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019) · cites this paper as Aldred et al., 2003
Citations
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URINARY HOMOVANILLIC ACID LEVELS OF AUTISTIC CHILDREN
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Cited by
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Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 940
Chauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656
The Intense World Theory – A Unifying Theory of the Neurobiology of Autism
Markram, H., & Markram, H. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00224 · Cited by 571
Mitochondrial dysfunction in autism
Giulivi, C., Zhang, Y.-F., Omanska-Klusek, A., Ross-Inta, C., Wong, S., Hertz-Picciotto, I., Tassone, F., & Pessah, I. N. (2010) · JAMA · doi:10.1001/jama.2010.1706 · Cited by 466
Metadata
- Authors
- Aldred, S., Moore, K. M., Fitzgerald, M., & Waring, R. H.
- Affiliations
- Aston University (GB)
- University of Birmingham (GB)
- Corresponding author
- Waring, Rosemary H.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2003-02
- Volume
- 33
- Issue
- 1
- Pages
- 93-97
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W1506956777
- Cited by
- 188
- References
- 18
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 12 · 2014: 13 · 2013: 7 · 2012: 11
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, Asperger syndrome, plasma amino acids, amino acid metabolism, glutamate, phenylalanine, asparagine, tyrosine, alanine, lysine, glutamine, siblings, parents
- MeSH terms
- Adolescent, Alanine, Amino Acids, Asparagine, Autistic Disorder, Child, Child, Preschool, Family, Female, Glutamine, Humans, Lysine, Male, Phenylalanine, Tyrosine, Glutamic Acid, Brain Diseases, Metabolic, Inborn, Asperger Syndrome
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