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Striking improvement of muscle strength under creatine therapy in a patient with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency
Abstract
Summary: Creatine monohydrate given orally led to a long‐lasting improvement of muscular weakness and ataxia in a girl with long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency
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“There appears to only be one case report of a patient with long chain β-OH acyl CoA-dehydrogenase (LCHAD) deficiency who lost the ability to walk at 11 y and was able to walk within a month of starting CrM (0.13 gram/kg/d) and was able to still walk, cycle and climb stairs at 16 years of age still on therapy [220].”
From Creatine monohydrate supplementation for older adults and clinical populations (2025) · cites this paper as [220]
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Research works printed but not linked: 3
- 10.1542/peds.109.1.99 · DOI
- 10.1212/WNL.52.4.854 · DOI · Paper page
- 10.1016/S0022-3476(97)70312-3 · DOI
Cited by
Clinical Use of Creatine in Neuromuscular and Neurometabolic Disorders
Tarnopolsky, M. A. (2007) · Subcellular Biochemistry · doi:10.1007/978-1-4020-6486-9_10 · Cited by 67
Creatine monohydrate supplementation for older adults and clinical populations
Candow, D. G., Ostojic, S. M., Chilibeck, P. D., Longobardi, I., Gualano, B., Tarnopolsky, M. A., Wallimann, T., Moriarty, T., Kreider, R. B., Forbes, S. C., et al. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2534130 · Cited by 43
Metadata
- Authors
- Korenke, G. C., Wanders, R. J. A., & Hanefeld, F.
- Affiliations
- Department of Paediatrics and Neuropaediatrics University of Göttingen Göttingen
- Department of Paediatrics University of Amsterdam Amsterdam The Netherlands
- Venue
- Journal of Inherited Metabolic Disease
- Publisher
- Wiley
- Published
- 2003-07
- Volume
- 26
- Issue
- 1
- Pages
- 67-68
- ISSN
- 0141-8955
- 1573-2665
- Cited by
- 4
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Striking improvement of muscle strength under creatine therapy in a patient with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. https://app.cochat.ai/papers/10.1023/a:1024031714659
- The paper
- Korenke, G. C., Wanders, R. J. A., & Hanefeld, F. (2003). Striking improvement of muscle strength under creatine therapy in a patient with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. Journal of Inherited Metabolic Disease. https://doi.org/10.1023/a%3A1024031714659
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
